Evidence map›Paper›PMID 37464990›Full record

ArticleFrontiers in neuroimaging2022

A guide for researchers seeking training in retrospective data harmonization for population neuroscience studies of Alzheimer's disease and related dementias.

C Elizabeth Shaaban, Dana L Tudorascu, M Maria Glymour, Ann D Cohen, Rebecca C Thurston, Heather M Snyder, Timothy J Hohman, Shubhabrata Mukherjee, Lan Yu, Beth E Snitz

Abstract read
In one paragraph

Article in Frontiers in neuroimaging, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
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  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

C Elizabeth ShaabanDepartment of Epidemiology, School of Public Health, University of Pittsburgh, Pittsburgh, PA, United States.
Dana L TudorascuDepartment of Psychiatry, School of Medicine, University of Pittsburgh, Pittsburgh, PA, United States.
M Maria GlymourDepartment of Epidemiology and Biostatistics, School of Medicine, University of California, San Francisco, San Francisco, CA, United States.
Ann D CohenDepartment of Psychiatry, School of Medicine, University of Pittsburgh, Pittsburgh, PA, United States.
Rebecca C ThurstonDepartment of Epidemiology, School of Public Health, University of Pittsburgh, Pittsburgh, PA, United States.
Heather M SnyderMedical and Scientific Relations, Alzheimer's Association, Chicago, IL, United States.
Timothy J HohmanVanderbilt Memory and Alzheimer's Center, Vanderbilt University Medical Center, Nashville, TN, United States.
Shubhabrata MukherjeeDepartment of Medicine, University of Washington, Seattle, WA, United States.
Lan YuDepartment of Medicine, School of Medicine, University of Pittsburgh, Pittsburgh, PA, United States.
Beth E SnitzDepartment of Neurology, School of Medicine, University of Pittsburgh, Pittsburgh, PA, United States.

Funding

Population neuroscience of sex differences in the Alzheimer's disease biomarker cascade: The role of cerebral small vessel diseaseK01AG071849 · NIA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI C. Elizabeth Shaaban · 2022 to 2026
$629k
NIA NIH HHS K01 AG071849
6 · The paper itself

Abstract

Due to needs surrounding rigor and reproducibility, subgroup specific disease knowledge, and questions of external validity, data harmonization is an essential tool in population neuroscience of Alzheimer's disease and related dementias (ADRD). Systematic harmonization of data elements is necessary to pool information from heterogeneous samples, and such pooling allows more expansive evaluations of health disparities, more precise effect estimates, and more opportunities to discover effective prevention or treatment strategies. The key goal of this Tutorial in Population Neuroimaging Curriculum, Instruction, and Pedagogy article is to guide researchers in creating a customized population neuroscience of ADRD harmonization training plan to fit their needs or those of their mentees. We provide brief guidance for retrospective data harmonization of multiple data types in this area, including: (1) clinical and demographic, (2) neuropsychological, and (3) neuroimaging data. Core competencies and skills are reviewed, and resources are provided to fill gaps in training as well as data needs. We close with an example study in which harmonization is a critical tool. While several aspects of this tutorial focus specifically on ADRD, the concepts and resources are likely to benefit population neuroscientists working in a range of research areas.

Indexed as

cognitive agingexternal validityneurocognitive testingneuroimagingneuropsychological assessmentpooling datasample size

Identifiers

PMID37464990
PMCPMC10353763

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.