ArticleJournal of clinical hypertension (Greenwich, Conn.)2023
The relationship between the systemic immune-inflammation index and reverse-dipper circadian pattern in newly diagnosed hypertensive patients.
Article in Journal of clinical hypertension (Greenwich, Conn.), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 2 of them syntheses that pooled it.
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Who cites it
23 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- The effects of ursodeoxycholic acid on cardiometabolic risk factors: a systematic review and meta-analysis of randomized controlled trials.BMC cardiovascular disorders · 2025Pooled it
- Correlation analysis of systemic immune inflammation index with the occurrence and clinical outcomes of hypertension: a systematic review and meta-analysis.Frontiers in cardiovascular medicine · 2025Pooled it
- Systemic Inflammatory Burden Is Independently Associated with Anemia After Transcatheter Aortic Valve Implantation in Patients Referred to Cardiac Rehabilitation.Biomedicines · 2026Article
- The comparison of cardiac and body morphometry in patients with non-dipper and reverse-dipper hypertension: a retrospective cross-sectional study.BMC cardiovascular disorders · 2026Article
- Angiotensin receptor-neprilysin inhibitors improve the outcome of lung cancer patients with hypertension undergoing immune checkpoint inhibitors treatment.BMC cardiovascular disorders · 2025Article
- Development of a risk factor nomogram prediction model for patients with acute coronary syndrome complicated by hypertension using LASSO regression analysis.BMC cardiovascular disorders · 2025Article
- U-Shaped Relationship Between White Blood Cell Counts and Incident Hypertension in Military Young Adults: The CHIEF Study, 2014-2020.Immunity, inflammation and disease · 2025Article
- Association of 24-h Blood Pressure Pattern With Mortality in ICU Patients: A Multicenter Retrospective Study.Journal of clinical hypertension (Greenwich, Conn.) · 2025Observational
- The use of systemic immune inflammatory index as a predictor for nematodes infections in horses.Parasite epidemiology and control · 2025Article
- SII as a predictor of mortality in patients with non-ST-segment elevation myocardial infarction and diabetes mellitus.Practical laboratory medicine · 2025Article
- Association between monocyte-to-lymphocyte ratio and cardiovascular diseases: insights from NHANES data.Diabetology & metabolic syndrome · 2025Article
- Triglyceride-glucose index and hsCRP-to-albumin ratio as predictors of major adverse cardiovascular events in STEMI patients with hypertension.Scientific reports · 2024Article
- The biomarkers associated with non-dipper pattern in patients with type 2 diabetes with hypertension.Medicine and pharmacy reports · 2024Article
- In emergency hypertension, could biomarkers change the guidelines?BMC cardiovascular disorders · 2024Article
- Association between systemic immunity-inflammation index and hypertension in US adults from NHANES 1999-2018.Scientific reports · 2024Article
- Relationship between systemic immune inflammation index and development of complete atrioventricular block in patients with ST-elevation myocardial infarction undergoing primary percutaneous coronary intervention.BMC cardiovascular disorders · 2024Article
- Proposal of a Modified Classification of Hypertensive Crises: Urgency, Impending Emergency, and Emergency.Current vascular pharmacology · 2024Review
- Association of Systemic Inflammation Level on Admission with Total and Cardiovascular‑Specific Death in Heart Failure with Preserved Ejection Fraction: A Large Multi‑Center Retrospective Longitudinal Study.Journal of inflammation research · 2024Article
- Therapeutical Approach to Arterial Hypertension - Current State of the Art.Current medicinal chemistry · 2024Review
- Exploring the utility of a latent variable as comprehensive inflammatory prognostic index in critically ill patients with cerebral infarction.Frontiers in neurology · 2024Article
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Although hypertension is considered high intravascular pressure, impairing circadian blood pressure (BP) has been shown to potentially contribute to poor clinical outcomes. Systemic immune-inflammation index (SII), based on platelet, neutrophil, and lymphocyte counts, has been established as a strong prognostic marker in cardiovascular disease. The role of inflammation in the pathogenesis of hypertension is a well-known issue and inflammatory markers are associated with BP variability. We aimed to investigate whether there is a relationship between circadian BP changes and SII in newly diagnosed hypertensive patients. The study population consisted of 196 newly diagnosed hypertensive patients without LVH. In total, 76 (38%) patients had a dipper BP pattern, 60 (31%) patients had a non-dipper BP pattern, and 60 (31%) patients had a reverse-dipper BP pattern. SII was calculated according to Multivariate logistic regression analysis revealed SII and HDL-C as an independent predictors of reverse-dipper circadian pattern in newly diagnosed hypertensive patients. The cut-off value of the SII for reverse-dipper hypertension in a ROC curve analysis was >639.73 with 63.3% sensitivity and 84.2% specificity. Our study showed that the SII level was higher in the reverse-dipper hypertension patient group than in the dipper and non-dipper hypertension groups. Furthermore, SII was an independent predictor of newly diagnosed reverse-dipper hypertensive patients. The high SII value in newly diagnosed hypertensive patients can be used as an early warning parameter to identify reverse-dipper hypertension patients.
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