Evidence map›Paper›PMID 37464581›Full record

ArticleJournal of applied clinical medical physics2023

Feasibility evaluation of novel AI-based deep-learning contouring algorithm for radiotherapy.

Luis A Maduro Bustos, Abhirup Sarkar, Laura A Doyle, Kelly Andreou, Jodie Noonan, Diana Nurbagandova, SunJay A Shah, Omoruyi Credit Irabor, Firas Mourtada

Open access · goldAbstract read
In one paragraph

Article in Journal of applied clinical medical physics, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
5.4field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 15 citations in OpenAlex.

  1. Trial
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  9. Development and validation of an AI-based lung lobe auto-contouring tool using radiation therapy planning free-breathing images.Reports of practical oncology and radiotherapy : journal of Greatpoland Cancer Center in Poznan and Polish Society of Radiation Oncology · 2025
    Article
  10. Article
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  12. Evaluation of multiple-vendor AI autocontouring solutions.Radiation oncology (London, England) · 2024
    Article
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Luis A Maduro BustosDepartment of Radiation Oncology, Christiana Care Helen F. Graham Cancer Center, Newark, Delaware, USA.
Abhirup SarkarDepartment of Radiation Oncology, Christiana Care Helen F. Graham Cancer Center, Newark, Delaware, USA.
Laura A DoyleDepartment of Radiation Oncology, Christiana Care Helen F. Graham Cancer Center, Newark, Delaware, USA.
Kelly AndreouDepartment of Radiation Oncology, Christiana Care Helen F. Graham Cancer Center, Newark, Delaware, USA.
Jodie NoonanDepartment of Radiation Oncology, Christiana Care Helen F. Graham Cancer Center, Newark, Delaware, USA.
Diana NurbagandovaDepartment of Radiation Oncology, Christiana Care Helen F. Graham Cancer Center, Newark, Delaware, USA.
SunJay A ShahDepartment of Radiation Oncology, Christiana Care Helen F. Graham Cancer Center, Newark, Delaware, USA.
Omoruyi Credit IraborDepartment of Radiation Oncology, Thomas Jefferson University Hospital, Philadelphia, Pennsylvania, USA.
Firas MourtadaDepartment of Radiation Oncology, Thomas Jefferson University Hospital, Philadelphia, Pennsylvania, USA.ORCID https://orcid.org/0000-0002-4388-5334
Christiana Care Health System · USThomas Jefferson University Hospital · US

Funding

X-Ray Crystallography and Macromolecular CharacterizationP30CA056036 · NCI · THOMAS JEFFERSON UNIVERSITY · PI DANIEL P SILVER · 1995 to 2026
$94.8M
NCI NIH HHS 5P30CA056036-17NCI NIH HHS P30 CA056036
6 · The paper itself

Abstract

purposeTo evaluate the clinical feasibility of the Siemens Healthineers AI-Rad Companion Organs RT VA30A (Organs-RT) auto-contouring algorithm for organs at risk (OARs) of the pelvis, thorax, and head and neck (H&N).

methodsComputed tomography (CT) datasets from 30 patients (10 pelvis, 10 thorax, and 10 H&N) were collected. Four sets of OARs were generated on each scan, one set by Organs-RT and the others by three experienced users independently. A physician (expert) then evaluated each contour by assigning a score from the following scale: 1-Must Redo, 2-Major Edits, 3-Minor Edits, 4-Clinically usable. Using the highest-scored OAR from the human users as a reference, the contours generated by Organs-RT were evaluated via Dice Similarity Coefficient (DSC), Hausdorff Distance (HDD), Mean Distance to Agreement (mDTA), Volume comparison, and visual inspection. Additionally, each human user recorded the time to delineate each structure set and time-saving efficiency was measured.

resultsThe average DSC obtained for the pelvic OARs ranged between (0.81 ± 0.06)

conclusionsThe highest agreement registered between OARs generated by Organs-RT and their respective references was for the bladder, heart, lungs, and femoral heads, with an overall DSC≥0.92. The poorest agreement was for the rectum, esophagus, and lips, with an overall DSC⩽0.81. Nonetheless, Organs-RT serves as a reliable auto-contouring tool by minimizing overall contouring time and increasing time-saving efficiency in radiotherapy treatment planning.

Indexed as

Deep LearningAlgorithmsFeasibility StudiesHumansNeckOrgans at RiskRadiotherapy Planning, Computer-Assistedartificial intelligencecontouringconvolutional neural networksdeep-learningsegmentation

Identifiers

PMID37464581
PMCPMC10647981
OpenAlexW4384663988

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.