Evidence map›Paper›PMID 37464359›Full record

ArticleMolecular brain2023

Antihyperalgesic effect of joint mobilization requires Cav3.2 calcium channels.

Daniel F Martins, Victor Sorrentino, Leidiane Mazzardo-Martins, William R Reed, Adair R S Santos, Vinícius M Gadotti, Gerald W Zamponi

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular brain, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact, top 84% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 0 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 3 countries.

Daniel F MartinsExperimental Neuroscience Laboratory (LaNEx), Postgraduate Program in Health Sciences, University of Southern Santa Catarina, Palhoça, SC, Brazil.
Victor SorrentinoExperimental Neuroscience Laboratory (LaNEx), Postgraduate Program in Health Sciences, University of Southern Santa Catarina, Palhoça, SC, Brazil.
Leidiane Mazzardo-MartinsExperimental Neuroscience Laboratory (LaNEx), Postgraduate Program in Health Sciences, University of Southern Santa Catarina, Palhoça, SC, Brazil.
William R ReedDepartment of Physical Therapy, Rehabilitation Science Program, University of Alabama at Birmingham, Birmingham, AL, USA.
Adair R S SantosPrograma de Pós-Graduação em Neurociências, Centro de Ciências Biológicas, Universidade Federal de Santa Catarina, Campus Universitário-Trindade, Florianópolis, SC, Brazil.
Vinícius M GadottiDepartments of Clinical Neurosciences, and Physiology & Pharmacology, Hotchkiss Brain Institute, Alberta Children's Hospital Research Institute, University of Calgary, Calgary, AB, T2N 4N1, Canada.
Gerald W ZamponiDepartments of Clinical Neurosciences, and Physiology & Pharmacology, Hotchkiss Brain Institute, Alberta Children's Hospital Research Institute, University of Calgary, Calgary, AB, T2N 4N1, Canada. zamponi@ucalgary.ca.ORCID 0000-0002-0644-9066
Universidade Federal de Santa Catarina · BRUniversity of Calgary · CAUniversidade do Sul de Santa Catarina · BRUniversity of Alabama at Birmingham · US

Funding

CIHR
6 · The paper itself

Abstract

The present study was undertaken to explore the relative contributions of Cav3.2 T-type channels to mediating the antihyperalgesic activity of joint manipulation (JM) therapy. We used the chronic constriction injury model (CCI) to induce peripheral neuropathy and chronic pain in male mice, followed by JM. We demonstrate that JM produces long-lasting mechanical anti-hyperalgesia that is abolished in Cav3.2 null mice. Moreover, we found that JM displays a similar analgesic profile as the fatty acid amide hydrolase inhibitor URB597, suggesting a possible converging mechanism of action involving endocannabinoids. Overall, our findings advance our understanding of the mechanisms through which JM produces analgesia.

Indexed as

AnalgesiaCalcium Channels, T-TypeAnalgesicsAnimalsHyperalgesiaMaleMicePainAnalgesicsCalcium Channels, T-TypeAnalgesiaCav3.2 channelJoint mobilization therapyMechanical hyperalgesia

Identifiers

PMID37464359
PMCPMC10355051
OpenAlexW4384664222

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.