Evidence map›Paper›PMID 37464230›Full record

ReviewMikrochimica acta2023

Recent advancements in the expedition of microneedles: from lab worktops to diagnostic care centers.

Megha Garg, Neha Jain, Shreya Kaul, Vineet Kumar Rai, Upendra Nagaich

Abstract readReview
PubMed Publisher
In one paragraph

Review in Mikrochimica acta, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.5field-weighted citation impact, top 43% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 4 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Megha GargDepartment of Pharmaceutics, Amity Institute of Pharmacy, Amity University, Noida, India.
Neha JainDepartment of Pharmaceutics, Amity Institute of Pharmacy, Amity University, Noida, India. njain1@amity.edu.
Shreya KaulDepartment of Pharmaceutics, Amity Institute of Pharmacy, Amity University, Noida, India.
Vineet Kumar RaiSchool of Pharmaceutical Sciences, Siksha 'o' Anusandhan University, Bhubaneswar, Odisha, 751003, India.
Upendra NagaichDepartment of Pharmaceutics, Amity Institute of Pharmacy, Amity University, Noida, India. upendra_nagaich@hotmail.com.ORCID http://orcid.org/0000-0003-0076-6885
Amity University · INSiksha O Anusandhan University · IN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Microneedle (MN) technology plays a significant role in bioengineering as it allows for minimally invasive exposure to the skin via the non-invasive procedure, increased drug permeability, and improved biological molecule detectability in the epidermal layers, all while improving therapeutic safety and effectiveness. However, MNs have several significant drawbacks, including difficulty scaling up, variability in drug delivery pattern regarding the skin's external environment, blockage of dermal tissues, induction of inflammatory response at the administration site, and limitation of dosing based on the molecular weight of drug and size. Despite these drawbacks, MNs have emerged as a special transdermal theranostics instrument in clinical research to assess physiological parameters. Bioimaging technology relies on microneedles that can measure particular analytes in the extracellular fluid effectively by crossing the stratum corneum, making them "a unique tool in diagnostics detection and therapeutic application inside the body." This review article discusses the recent advances in the applications especially related to the diagnostics and toxicity challenges of microneedles. In addition, this review article discusses the clinical state and commercial accessibility of microneedle technology-based devices in order to provide new information to scientists and researchers.

Indexed as

ExpeditionsAdministration, CutaneousEpidermisPharmaceutical PreparationsSkinPharmaceutical PreparationsDiagnosisMarket trendsNon-invasiveProduct pipeline analysisTheranostics

Identifiers

PMID37464230
OpenAlexW4384664660

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.