Evidence map›Paper›PMID 37464192›Full record

ArticleCancer immunology, immunotherapy : CII2023

Piper nigrum extract suppresses tumor growth and enhances the antitumor immune response in murine models of breast cancer and melanoma.

Paola Lasso, Laura Rojas, Cindy Arévalo, Claudia Urueña, Natalia Murillo, Paula Nossa, Tito Sandoval, Luis Carlos Chitiva, Alfonso Barreto, Geison M Costa and 1 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cancer immunology, immunotherapy : CII, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
3.9field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 16 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 1 institution in 1 country.

Paola LassoGrupo de Inmunobiología y Biología Celular, Pontificia Universidad Javeriana, Carrera 7a. No. 43-82, Ed. 50, Lab. 101, Bogotá, C.P. 110211, Colombia.
Laura RojasGrupo de Inmunobiología y Biología Celular, Pontificia Universidad Javeriana, Carrera 7a. No. 43-82, Ed. 50, Lab. 101, Bogotá, C.P. 110211, Colombia.
Cindy ArévaloGrupo de Inmunobiología y Biología Celular, Pontificia Universidad Javeriana, Carrera 7a. No. 43-82, Ed. 50, Lab. 101, Bogotá, C.P. 110211, Colombia.
Claudia UrueñaGrupo de Inmunobiología y Biología Celular, Pontificia Universidad Javeriana, Carrera 7a. No. 43-82, Ed. 50, Lab. 101, Bogotá, C.P. 110211, Colombia.
Natalia MurilloGrupo de Inmunobiología y Biología Celular, Pontificia Universidad Javeriana, Carrera 7a. No. 43-82, Ed. 50, Lab. 101, Bogotá, C.P. 110211, Colombia.
Paula NossaGrupo de Inmunobiología y Biología Celular, Pontificia Universidad Javeriana, Carrera 7a. No. 43-82, Ed. 50, Lab. 101, Bogotá, C.P. 110211, Colombia.
Tito SandovalGrupo de Inmunobiología y Biología Celular, Pontificia Universidad Javeriana, Carrera 7a. No. 43-82, Ed. 50, Lab. 101, Bogotá, C.P. 110211, Colombia.
Luis Carlos ChitivaGrupo de Investigación en Fitoquímica, Pontificia Universidad Javeriana, Bogotá, Colombia.
Alfonso BarretoGrupo de Inmunobiología y Biología Celular, Pontificia Universidad Javeriana, Carrera 7a. No. 43-82, Ed. 50, Lab. 101, Bogotá, C.P. 110211, Colombia.
Geison M CostaGrupo de Investigación en Fitoquímica, Pontificia Universidad Javeriana, Bogotá, Colombia.
Susana FiorentinoGrupo de Inmunobiología y Biología Celular, Pontificia Universidad Javeriana, Carrera 7a. No. 43-82, Ed. 50, Lab. 101, Bogotá, C.P. 110211, Colombia. susana.fiorentino@javeriana.edu.co.
Pontificia Universidad Javeriana · CO

Funding

Pontificia Universidad Javeriana, Ministerio de Ciencia, Tecnología e Innovación, Ministerio de Educación Nacional, Ministerio de Industria, Comercio y Turismo and ICETEX, 2ª Convocatoria Ecosistema Científico - Colombia Científica 792-2017 FP44842-221-2018
6 · The paper itself

Abstract

Although the antitumor effect of P. nigrum has been widely studied, research related to its possible immunomodulatory effects is relatively scarce. Here, the antitumor and immunomodulatory activity of an ethanolic extract of P. nigrum were evaluated in the murine models of 4T1 breast cancer and B16-F10 melanoma. In vitro evaluations showed that the P. nigrum extract has cytotoxic activity, induces apoptotic cell death, and has a pro-oxidant effect in both cell lines, but it regulates glucose uptake differently in both lines, decreasing it in 4T1 but not in B16-F10. P. nigrum extract significantly reduced tumor size in both models and decreased the occurrence of macrometastases in 4T1 model. Evaluation of immune subpopulations by flow cytometry revealed that the P. nigrum extract significantly increases the frequency of dendritic cells and activated CD8

Indexed as

Breast NeoplasmsMelanoma, ExperimentalPiper nigrumAnimalsCD8-Positive T-LymphocytesDisease Models, AnimalFemaleHumansImmunityMicePlant ExtractsTumor MicroenvironmentPlant ExtractsAntitumorBreast cancerImmunomodulationMelanomaPiper nigrumPlant extracts

Identifiers

PMID37464192
PMCPMC10491708
OpenAlexW4384664762

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.