Evidence map›Paper›PMID 37464169›Full record

ArticleBiological trace element research2024

Antibacterial Activity of Boron Compounds Against Biofilm-Forming Pathogens.

Ozgur Celebi, Demet Celebi, Sumeyye Baser, Elif Aydın, Erva Rakıcı, Serpil Uğraş, Pınar Ağyar Yoldaş, Nurcan Kılıç Baygutalp, A M Abd El-Aty

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Article in Biological trace element research, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
7.6field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 33 citations in OpenAlex.

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  13. TiOScientific reports · 2025
    Article
  14. Proteomic profiling ofTurkish journal of biology = Turk biyoloji dergisi · 2025
    Article
  15. Activity of zinc oxide and zinc borate nanoparticles against resistant bacteria in an experimental lung cancer model.Daru : journal of Faculty of Pharmacy, Tehran University of Medical Sciences · 2024
    Article
  16. Review
  17. Article
  18. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 1 country.

Ozgur CelebiDepartment of Medical Microbiology, Faculty of Medicine, Ataturk University, 25240, Erzurum, Turkey.ORCID http://orcid.org/0000-0003-4578-9474
Demet CelebiDepartment of Microbiology, Faculty of Veterinary Medicine, Ataturk University, 25240, Erzurum, Turkey.ORCID http://orcid.org/0000-0002-2355-0561
Sumeyye BaserDepartment of Medical Microbiology, Faculty of Medicine, Ataturk University, 25240, Erzurum, Turkey.ORCID http://orcid.org/0000-0003-2391-8191
Elif AydınVocational School of Health Services, Kütahya Health Sciences University, Kütahya, Turkey. elif.aydin@ksbu.edu.tr.ORCID http://orcid.org/0000-0003-0877-453X
Erva RakıcıDepartment of Medical Microbiology, Faculty of Medicine, Recep Tayyip Erdogan University, 53020, Rize, Turkey.ORCID http://orcid.org/0000-0002-4464-4882
Serpil UğraşDepartment of Field Crops, Faculty of Agriculture and Natural Science, Duzce University, 81620, Düzce, Turkey.ORCID http://orcid.org/0000-0002-1867-5781
Pınar Ağyar YoldaşTraditional and Complementary Medicine Applied and Research Center, Duzce University, Duzce, Turkey.ORCID http://orcid.org/0000-0002-9277-0648
Nurcan Kılıç BaygutalpDepartment of Biochemistry, Faculty of Pharmacy, Ataturk University, 25240, Erzurum, Turkey.ORCID http://orcid.org/0000-0002-3584-5252
A M Abd El-AtyDepartment of Medical Pharmacology, Faculty of Medicine, Ataturk University, 25240, Erzurum, Turkey.ORCID http://orcid.org/0000-0001-6596-7907
Atatürk University · TRDüzce Üniversitesi · TRIstanbul Aydın University · TRRecep Tayyip Erdoğan University · TR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This study aimed to evaluate the antibacterial activity of nine boron derivatives against biofilm-forming pathogenic bacteria. The effect of boron derivatives (CMB, calcium metaborate; SMTB, sodium metaborate tetrahydrate; ZB, zinc borate; STFB, sodium tetra fluorine borate; STB, sodium tetraborate; PTFB, potassium tetra fluor borate; APTB, ammonium pentabo-rate tetrahydrate; SPM, sodium perborate monohydrate; Borax, ATFB, ammonium tetra fluorine borate) on bacteria isolated from blood culture was determined by the minimum inhibitory concentration (MIC) method. Then, biofilm formation potentials on microplates, tubes, and Congo red agar were examined. The cytotoxicity of boron derivatives was determined by using WST-1-based methods. The interaction between the biofilm-forming bacteria, fibroblast cells, and boron derivatives was determined with the infection model. We found that the sodium metaborate tetrahydrate molecule was effective against all pathogens. According to the optical density values detected at 630 nm in microplates, meticillin-resistant Staphylococcus aureus was observed to have the most substantial biofilm ability at 0.257 nm. As a result of cytotoxicity studies, it has been determined that a 1 µg/L concentration of boron derivatives is not toxic to fibroblast L929 cells. In cell culture experiments, these boron derivatives have very serious inhibitory activity against biofilm-forming pathogens in a short treatment period, such as 2-4 h. Furthermore, using these molecules on inanimate surfaces affected by biofilms would be appropriate instead of living cells.

Indexed as

Ammonium CompoundsMethicillin-Resistant Staphylococcus aureusAnti-Bacterial AgentsBacteriaBiofilmsBoratesBoronBoron CompoundsFluorineMicrobial Sensitivity Testsammonium borateAmmonium CompoundsAnti-Bacterial AgentsBoratesboraxBoronBoron CompoundsFluorinesodium borateAntibacterial activityBiofilmBoron derivativesCell cultureMinimum inhibitory concentration

Identifiers

PMID37464169
OpenAlexW4384664659

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.