Evidence map›Paper›PMID 37464143›Full record

Trial reportJournal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract2023

Pain and Opioid Consumption After Laparoscopic Versus Open Gastrectomy for Gastric Cancer: A Secondary Analysis of a Multicenter Randomized Clinical Trial (LOGICA-Trial).

Arjen van der Veen, Mark Ramaekers, Marije Marsman, Hylke J F Brenkman, Maarten F J Seesing, Misha D P Luyer, Grard A P Nieuwenhuijzen, Jan H M B Stoot, Juul J W Tegels, Bas P L Wijnhoven and 10 more

Registry-linked trialOpen access · hybridAbstract readRandomized Controlled TrialMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02248519 (Laparoscopic Versus Open Gastrectomy for Gastric Cancer, a Multicenter Prospectively Randomized Controlled Trial), which is not on this map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.3field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02248519 nacompletednot on this map

Laparoscopic Versus Open Gastrectomy for Gastric Cancer, a Multicenter Prospectively Randomized Controlled Trial (LOGICA-trial)

TypeinterventionalSponsorUMC UtrechtRan2014 to 2023Enrolled210ConditionsGastric CancerArmsOpen Gastrectomy, Laparoscopic Gastrectomy
3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 5 citations in OpenAlex.

  1. Observational
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors at 15 institutions in 2 countries.

Arjen van der VeenDepartment of Surgery, University Medical Center Utrecht, Utrecht University, Heidelberglaan 100 G04.228, 3508 GA, Utrecht, Netherlands. a.vanderveen-12@umcutrecht.nl.
Mark RamaekersDepartment of Surgery, Catharina Hospital, Eindhoven, Netherlands.
Marije MarsmanDepartment of Anesthesiology, University Medical Center Utrecht, Utrecht University, Utrecht, Netherlands.
Hylke J F BrenkmanDepartment of Surgery, University Medical Center Utrecht, Utrecht University, Heidelberglaan 100 G04.228, 3508 GA, Utrecht, Netherlands.
Maarten F J SeesingDepartment of Surgery, University Medical Center Utrecht, Utrecht University, Heidelberglaan 100 G04.228, 3508 GA, Utrecht, Netherlands.
Misha D P LuyerDepartment of Surgery, Catharina Hospital, Eindhoven, Netherlands.
Grard A P NieuwenhuijzenDepartment of Surgery, Catharina Hospital, Eindhoven, Netherlands.
Jan H M B StootDepartment of Surgery, Zuyderland Medical Center, Heerlen and Sittard-Geleen, Netherlands.
Juul J W TegelsDepartment of Surgery, Zuyderland Medical Center, Heerlen and Sittard-Geleen, Netherlands.
Bas P L WijnhovenDepartment of Surgery, Erasmus University Medical Center, Rotterdam, Netherlands.
Wobbe O de SteurDepartment of Surgery, Leiden University Medical Center, Leiden, Netherlands.
Ewout A KouwenhovenDepartment of Surgery, ZGT Hospitals, Almelo, Netherlands.
Eelco B WassenaarDepartment of Surgery, Gelre Hospitals, Apeldoorn, Netherlands.
Werner A DraaismaDepartment of Surgery, Meander Medical Center, Amersfoort, Netherlands.
Suzanne S GisbertzDepartment of Surgery, Amsterdam UMC, Location AMC, University of Amsterdam, Cancer Center Amsterdam, Amsterdam, Netherlands.
Donald L van der PeetDepartment of Surgery, Amsterdam UMC, Location VUmc, University of Amsterdam, Cancer Center Amsterdam, Amsterdam, Netherlands.
Anne M MayUniversity Medical Center Utrecht, Utrecht University, Julius Center for Health Sciences and Primary Care, Utrecht, Netherlands.
Jelle P RuurdaDepartment of Surgery, University Medical Center Utrecht, Utrecht University, Heidelberglaan 100 G04.228, 3508 GA, Utrecht, Netherlands.
Richard van HillegersbergDepartment of Surgery, University Medical Center Utrecht, Utrecht University, Heidelberglaan 100 G04.228, 3508 GA, Utrecht, Netherlands. r.vanhillegersberg@umcutrecht.nl.
LOGICA study group
Zuyderland Medisch Centrum · NLErasmus MC · NLGelre Hospitals · NLRadboud University Nijmegen · NLUniversity Medical Center Utrecht · NLAmsterdam UMC Location Vrije Universiteit Amsterdam · NLCatharina Ziekenhuis · NLHeidelberg University · DELeiden University Medical Center · NLMeander Medisch Centrum · NLUtrecht University · NLZiekenhuis Groep Twente · NLCancer Center Amsterdam · NLUniversity Hospital Heidelberg · DEUniversity of Amsterdam · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundLaparoscopic gastrectomy could reduce pain and opioid consumption, compared to open gastrectomy. However, it is difficult to judge the clinical relevance of this reduction, since these outcomes are reported in few randomized trials and in limited detail.

methodsThis secondary analysis of a multicenter randomized trial compared laparoscopic versus open gastrectomy for resectable gastric adenocarcinoma (cT1-4aN0-3bM0). Postoperative pain was analyzed by opioid consumption in oral morphine equivalents (OME, mg/day) at postoperative day (POD) 1-5, WHO analgesic steps, and Numeric Rating Scales (NRS, 0-10) at POD 1-10 and discharge. Regression and mixed model analyses were performed, with and without correction for epidural analgesia.

resultsBetween 2015 and 2018, 115 patients in the laparoscopic group and 110 in the open group underwent surgery. Some 16 patients (14%) in the laparoscopic group and 73 patients (66%) in the open group received epidural analgesia. At POD 1-3, mean opioid consumption was 131, 118, and 53 mg OME lower in the laparoscopic group, compared to the open group, respectively (all p < 0.001). After correcting for epidural analgesia, these differences remained significant at POD 1-2 (47 mg OME, p = 0.002 and 69 mg OME, p < 0.001, respectively). At discharge, 27% of patients in the laparoscopic group and 43% patients in the open group used oral opioids (p = 0.006). Mean highest daily pain scores were between 2 and 4 at all PODs, < 2 at discharge, and did not relevantly differ between treatment arms.

conclusionIn this multicenter randomized trial, postoperative pain was comparable between laparoscopic and open gastrectomy. After laparoscopic gastrectomy, this was generally achieved without epidural analgesia and with fewer opioids.

trial registrationNCT02248519.

Indexed as

LaparoscopyStomach NeoplasmsAnalgesics, OpioidGastrectomyHumansPostoperative PainAnalgesics, OpioidGastrectomyGastric cancerLaparoscopic gastrectomyOpioid consumptionPainRandomized trialSurgery

Identifiers

PMID37464143
PMCPMC10579125
OpenAlexW4384661957

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.