Evidence map›Paper›PMID 37464065›Full record

ArticleSurgical endoscopy2023

Prevalence and risk factors for secondary hyperparathyroidism (SHPT) in patients undergoing bariatric surgery.

Laura E Fischer, Fernando Moreno-Garcia, Rachel Tran, Allison Harmon, Cooper Little, Grayson Domingue, Kenneth Stewart, Fernando Mier Giraud, Rishi Thakral

Abstract read
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Article in Surgical endoscopy, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
2.2field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 7 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Laura E FischerDepartment of Surgery, University of Oklahoma, Oklahoma City, USA. laura-fischer@ouhsc.edu.ORCID http://orcid.org/0000-0001-7460-3283
Fernando Moreno-GarciaUniversity of Oklahoma School of Medicine, Oklahoma City, USA.
Rachel TranUniversity of Oklahoma School of Medicine, Oklahoma City, USA.
Allison HarmonUniversity of Oklahoma School of Medicine, Oklahoma City, USA.
Cooper LittleUniversity of Oklahoma School of Medicine, Oklahoma City, USA.
Grayson DomingueDepartment of Orthopedic Surgery, University of Oklahoma, Oklahoma City, USA.
Kenneth StewartDepartment of Surgery, University of Oklahoma, Oklahoma City, USA.
Fernando Mier GiraudDepartment of Surgery, University of Oklahoma, Oklahoma City, USA.
Rishi ThakralDepartment of Orthopedic Surgery, University of Oklahoma, Oklahoma City, USA.
University of Oklahoma · USOklahoma City University · USUniversity of Oklahoma Health Sciences Center · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionSecondary hyperparathyroidism (SHPT) after bariatric surgery has significant adverse implications for bone metabolism, increasing the risk for osteoporosis and fracture. Our aim was to characterize prevalence and identify risk factors for SHPT in bariatric surgery patients.

methodsWe performed a single-institution, retrospective chart review of patients who underwent bariatric surgery from June 2017 through December 2021. Demographic and clinical data were collected, including serum parathyroid hormone, calcium, and vitamin D3 at enrollment and 3, 6, and 12-months postoperatively. Chi-square or Fisher's exact tests were used to analyze categorical data and Mann-Whitney U test for continuous data. Multivariable analysis using binomial logistic regression assessed risk factors for SHPT. P-values ≤ 0.05 were considered significant.

results350 patients were analyzed. SHPT prevalence at any time point was 72.9%. 65.8% had SHPT at enrollment; 45.9% resolved with intensive vitamin supplementation; and 19.7% had recurrent SHPT. New-onset SHPT occurred in 8.6%. Persistent SHPT was present in 42.4% at 1-year. Baseline SHPT correlated with black race and T2DM. SHPT at any time point correlated with T2DM and higher baseline BMI. 1-year SHPT correlated with RYGB, depression, and longer time in program. SHPT was not correlated with %TBWL at any time point. In patients with SHPT, vitamin D3 deficiency prevalence was significantly higher at baseline (77.0%) compared to all post-bariatric time points (16.7%, 17.3%, and 23.1%; P < 0.0001).

conclusionsSHPT is highly prevalent in patients with obesity seeking weight loss surgery. 42% had persistent SHPT at 1-year despite appropriate vitamin supplementation. Current vitamin D3 and calcium supplementation protocols may not effectively prevent SHPT in many post-bariatric patients. Low prevalence of concomitant vitamin D3 deficiency with SHPT after bariatric surgery suggests that there may be alternative mechanisms in this population. Further studies are needed to develop effective treatment strategies to mitigate the adverse effects of bariatric surgery on bone metabolism.

Indexed as

Bariatric SurgeryDiabetes Mellitus, Type 2Hyperparathyroidism, SecondaryVitamin D DeficiencyCalciumCholecalciferolHumansParathyroid HormonePrevalenceRetrospective StudiesRisk FactorsVitamin DVitaminsCalciumCholecalciferolParathyroid HormoneVitamin DVitaminsBariatric surgeryFractureOsteoporosisParathyroid hormoneSecondary hyperparathyroidismVitamin D3 deficiency

Identifiers

PMID37464065
OpenAlexW4384662349

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.