Evidence map›Paper›PMID 37464048›Full record

ArticleNature medicine2023

Disease risk and healthcare utilization among ancestrally diverse groups in the Los Angeles region.

Christa Caggiano, Arya Boudaie, Ruhollah Shemirani, Joel Mefford, Ella Petter, Alec Chiu, Defne Ercelen, Rosemary He, Daniel Tward, Kimberly C Paul and 9 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Genetic risk effects on psychiatric disorders act in sets.medRxiv : the preprint server for health sciences · 2025
    Article
  8. Article
  9. Review
  10. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

19 authors.

Christa CaggianoInterdepartmental Program in Bioinformatics, University of California, Los Angeles, Los Angeles, CA, USA.
Arya BoudaieOscar Health, Inc., New York, NY, USA.
Ruhollah ShemiraniInstitute for Genomic Health, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Joel MeffordSemel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, Los Angeles, CA, USA.
Ella PetterDepartment of Computer Science, University of California, Los Angeles, Los Angeles, CA, USA.
Alec ChiuInterdepartmental Program in Bioinformatics, University of California, Los Angeles, Los Angeles, CA, USA.
Defne ErcelenComputational and Systems Biology Interdepartmental Program, University of California, Los Angeles, Los Angeles, CA, USA.
Rosemary HeDepartment of Computer Science, University of California, Los Angeles, Los Angeles, CA, USA.
Daniel TwardDepartment of Neurology, University of California, Los Angeles, Los Angeles, CA, USA.
Kimberly C PaulDepartment of Neurology, University of California, Los Angeles, Los Angeles, CA, USA.
Timothy S ChangDepartment of Neurology, University of California, Los Angeles, Los Angeles, CA, USA.
Bogdan PasaniucDepartment of Computational Medicine, University of California, Los Angeles, Los Angeles, CA, USA.
Eimear E KennyInstitute for Genomic Health, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Jonathan A ShorttColorado Center for Personalized Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.ORCID http://orcid.org/0000-0002-7980-5420
Christopher R GignouxColorado Center for Personalized Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
Brunilda BalliuDepartment of Computational Medicine, University of California, Los Angeles, Los Angeles, CA, USA.
Valerie A ArboledaDepartment of Pathology and Laboratory Medicine, University of California, Los Angeles, Los Angeles, CA, USA.
Gillian BelbinInstitute for Genomic Health, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Noah ZaitlenDepartment of Neurology, University of California, Los Angeles, Los Angeles, CA, USA. nzaitlen@ucla.edu.ORCID http://orcid.org/0000-0002-3553-3670

Funding

Polygenic Risk Scores for Diverse Populations - Bridging Research and Clinical CareR01HL151152 · NHLBI · FRED HUTCHINSON CANCER RESEARCH CENTER · PI Christy Leigh Avery, Jennifer Below · 2020 to 2026
$12.3M
Training Grant in Genomic Analysis and InterpretationT32HG002536 · NHGRI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Valerie A Arboleda, Harold Pimentel · 2002 to 2026
$8.6M
PAGE III: Population Architecture using Genomics and EpidemiologyR01HG010297 · NHGRI · RUTGERS, THE STATE UNIV OF N.J. · PI GIGNOUX, CHRISTOPHER R, MATISE, TARA C. · 2019 to 2022
$6.5M
Methods for Genome-wide Association Studies in Admixed PopulationsR01HG006399 · NHGRI · HARVARD UNIVERSITY D/B/A HARVARD SCHOOL OF PUBLIC HEALTH · PI PRICE, ALKES L · 2011 to 2024
$6.3M
PRS Center for Admixed Populations (CAPE)U01HG011715 · NHGRI · UNIVERSITY OF PENNSYLVANIA · PI Eimear Elizabeth Kenny, Leslie A Lange · 2021 to 2026
$5.2M
Optimizing imputation for diverse populations in a distributed frameworkU01HG009080 · NHGRI · STANFORD UNIVERSITY · PI KENNY, EIMEAR ELIZABETH · 2016 to 2020
$5.2M
Improved methods for inference of genotype-specific response to environmental toxinsR01ES029929 · NIEHS · PRINCETON UNIVERSITY · PI AYROLES, JULIEN, CLARK, ANDREW G · 2019 to 2023
$3.6M
(PQ3) A functional genomic approach to identification and interpretation of germline-tumor genetic interactionsR01CA227237 · NCI · DANA-FARBER CANCER INST · PI GUSEV, ALEXANDER, ZAITLEN, NOAH A · 2018 to 2022
$3.5M
Genomic Approaches to Population Health in Multi-Ethnic Hospital SystemsR01HG011345 · NHGRI · UNIVERSITY OF COLORADO DENVER · PI ARBOLEDA, VALERIE A, GIGNOUX, CHRISTOPHER R · 2020 to 2023
$3.1M
Epigenomics of asthma risk factors and clinical subtypes in minority childrenR01HL155024 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI BORRELL, LUISA N, ZAITLEN, NOAH A · 2021 to 2024
$2.9M
Rarely Common: Uncovering the dominant role of rare variants in the genetic architecture of complex human traits.R01GM142112 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI HERNANDEZ, RYAN D. · 2021 to 2024
$2.2M
Unraveling correlations between Mendelian and common disease using functional genomicsDP5OD024579 · OD · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ARBOLEDA, VALERIE A · 2017 to 2021
$1.9M
NCI NIH HHS R01 CA227237NHGRI NIH HHS R01 HG006399NHGRI NIH HHS R01 HG010297NHGRI NIH HHS R01 HG011345NHGRI NIH HHS T32 HG002536NHGRI NIH HHS U01 HG009080NHGRI NIH HHS U01 HG011715NHLBI NIH HHS R01 HL151152NHLBI NIH HHS R01 HL155024NIA NIH HHS K01 AG072044NIEHS NIH HHS R01 ES029929NIGMS NIH HHS R01 GM142112NIH HHS DP5 OD024579NIMHD NIH HHS R56 MD013312NIMH NIH HHS R01 MH122688NINDS NIH HHS F31 NS122538
6 · The paper itself

Abstract

An individual's disease risk is affected by the populations that they belong to, due to shared genetics and environmental factors. The study of fine-scale populations in clinical care is important for identifying and reducing health disparities and for developing personalized interventions. To assess patterns of clinical diagnoses and healthcare utilization by fine-scale populations, we leveraged genetic data and electronic medical records from 35,968 patients as part of the UCLA ATLAS Community Health Initiative. We defined clusters of individuals using identity by descent, a form of genetic relatedness that utilizes shared genomic segments arising due to a common ancestor. In total, we identified 376 clusters, including clusters with patients of Afro-Caribbean, Puerto Rican, Lebanese Christian, Iranian Jewish and Gujarati ancestry. Our analysis uncovered 1,218 significant associations between disease diagnoses and clusters and 124 significant associations with specialty visits. We also examined the distribution of pathogenic alleles and found 189 significant alleles at elevated frequency in particular clusters, including many that are not regularly included in population screening efforts. Overall, this work progresses the understanding of health in understudied communities and can provide the foundation for further study into health inequities.

Indexed as

Delivery of Health CarePatient Acceptance of Health CareEthnicityHumansIranLos Angeles

Identifiers

PMID37464048
PMCPMC11121511

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.