Evidence map›Paper›PMID 37464010›Full record

ArticleScientific reports2023

Macrophage migration inhibitory factor (MIF) and its homolog D-dopachrome tautomerase (D-DT) are significant promotors of UVB- but not chemically induced non-melanoma skin cancer.

Sebastian Huth, Laura Huth, Ruth Heise, Yvonne Marquardt, Linda Lopopolo, Marta Piecychna, Peter Boor, Günter Fingerle-Rowson, Aphrodite Kapurniotu, Amir S Yazdi and 3 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.3field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 5 institutions in 2 countries.

Sebastian Huth *Department of Dermatology and Allergology, Medical Faculty, RWTH Aachen University, Pauwelsstrasse 30, 52074, Aachen, Germany. shuth@ukaachen.de.ORCID 0000-0003-4701-3864
Laura Huth *Department of Dermatology and Allergology, Medical Faculty, RWTH Aachen University, Pauwelsstrasse 30, 52074, Aachen, Germany.
Ruth HeiseDepartment of Dermatology and Allergology, Medical Faculty, RWTH Aachen University, Pauwelsstrasse 30, 52074, Aachen, Germany.
Yvonne MarquardtDepartment of Dermatology and Allergology, Medical Faculty, RWTH Aachen University, Pauwelsstrasse 30, 52074, Aachen, Germany.
Linda LopopoloDepartment of Dermatology and Allergology, Medical Faculty, RWTH Aachen University, Pauwelsstrasse 30, 52074, Aachen, Germany.
Marta PiecychnaDepartment of Medicine, Yale School of Medicine, New Haven, CT, USA.
Peter BoorInstitute of Pathology and Department of Nephrology and Immunology, Medical Faculty, RWTH Aachen University, Aachen, Germany.
Günter Fingerle-RowsonDepartment I of Internal Medicine, Center of Integrated Oncology Köln Bonn, University Hospital of Cologne, Cologne, Germany.
Aphrodite KapurniotuDivision of Peptide Biochemistry, School of Life Sciences, Technical University of Munich (TUM), Freising, Germany.
Amir S YazdiDepartment of Dermatology and Allergology, Medical Faculty, RWTH Aachen University, Pauwelsstrasse 30, 52074, Aachen, Germany.
Richard BucalaDepartment of Medicine, Yale School of Medicine, New Haven, CT, USA.
Jürgen BernhagenDivision of Vascular Biology, Institute for Stroke and Dementia Research (ISD), Ludwig-Maximilians-University (LMU), Munich, Germany.
Jens Malte BaronDepartment of Dermatology and Allergology, Medical Faculty, RWTH Aachen University, Pauwelsstrasse 30, 52074, Aachen, Germany.
RWTH Aachen University · DEYale University · USLudwig-Maximilians-Universität München · DETechnical University of Munich · DEUniversity Hospital Cologne · DE

Funding

Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
Defining the Pathogenic Contribution of High Genotypic MIF ExpressionR01AR078334 · NIAMS · YALE UNIVERSITY · PI BUCALA, RICHARD J · 2021 to 2025
$1.8M
NCATS NIH HHS UL1 TR001863NIAMS NIH HHS R01 AR078334
6 · The paper itself

Abstract

Non-melanoma skin cancer (NMSC) is the most common cancer in Caucasians worldwide. We investigated the pathophysiological role of MIF and its homolog D-DT in UVB- and chemically induced NMSC using Mif

Indexed as

Macrophage Migration-Inhibitory FactorsSkin NeoplasmsAnimalsIntramolecular OxidoreductasesMiceMice, Knockoutdopachrome isomeraseIntramolecular OxidoreductasesMacrophage Migration-Inhibitory FactorsMif protein, mouse

Identifiers

PMID37464010
PMCPMC10354066
OpenAlexW4384663600

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.