ArticleScientific reports2023
The effect of long-term cigarette smoking on selected skin barrier proteins and lipids.
Article in Scientific reports, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
15 citing papers in PubMed.
- Topical Mupirocin Treatment Reduces Interferon and Myeloid Signatures in Cutaneous Lupus Erythematous Lesions Through Targeting of Staphylococcus Species.Arthritis & rheumatology (Hoboken, N.J.) · 2025Trial
- Smoking-related variation in facial soft tissue thickness assessed by ultrasound: forensic implications for facial analysis.Die Naturwissenschaften · 2026Article
- Association between smoking and physical attractiveness: A longitudinal panel study from the China Family Panel Studies.Tobacco induced diseases · 2026Article
- No Evidence for a Genetic Causal Association Between Smoking and Urticaria: A Mendelian Randomization Study.Clinical, cosmetic and investigational dermatology · 2026Article
- Cutaneous lupus erythematosus - from pathogenesis to targeted therapy.Nature reviews. Rheumatology · 2025Review
- Chronic Pruritus in Older Adults: Prevalence, Associations, and Pruritus-specific Quality of Life.Acta dermato-venereologica · 2025Article
- Chronic cough and chronic pruritus in older adults: a population-based cross-sectional study.ERJ open research · 2025Article
- Can cardiovascular health and its modifiable healthy lifestyle offset the increased risk of all-cause and cardiovascular deaths associated with insulin resistance?Cardiovascular diabetology · 2025Article
- Impact of smoking habit on the subgingival proteome in patients with periodontitis.Journal of periodontology · 2025Article
- Role of ferroptosis-related IREB2 in the shared genetic etiology between smoking and facial aging: Insights from large-scale genome-wide cross-trait analysis.Computational and structural biotechnology journal · 2025Article
- Antimicrobial photodynamic therapy for severe acute radiodermatitis in patients undergoing head and neck radiotherapy: a case series.Frontiers in oncology · 2025Article
- Skin Markers of Premature Ageing in Patients with COPD: Results Form COSYCONET.Journal of clinical medicine · 2024Article
- Prevention of Melasma During Pregnancy: Risk Factors and Photoprotection-Focused Strategies.Clinical, cosmetic and investigational dermatology · 2024Review
- Radiation-induced skin injury in the head and neck region: pathogenesis, clinics, prevention, treatment considerations and proposal for management algorithm.Reports of practical oncology and radiotherapy : journal of Greatpoland Cancer Center in Poznan and Polish Society of Radiation Oncology · 2024Review
- Hypovitaminosis D in university workers in Southern Ecuador: interactions between gender and lifestyle.Frontiers in nutrition · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The negative impact of cigarette smoking on the skin includes accelerated aging, pigmentation disorders, and impaired wound healing, but its effect on the skin barrier is not completely understood. Here, we studied the changes in selected epidermal proteins and lipids between smokers (45-66 years, smoking > 10 years, > 10 cigarettes per day) and non-smokers. Volar forearm epidermal and stratum corneum samples, obtained by suction blister and tape stripping, respectively, showed increased thickness in smokers. In the epidermis of smokers, we observed a significant upregulation of filaggrin, loricrin, and a trend of increased involucrin but no differences were found in the case of transglutaminase 1 and kallikrein-related peptidase 7, on the gene and protein levels. No significant changes were observed in the major skin barrier lipids, except for increased cholesterol sulfate in smokers. Liquid chromatography coupled with mass spectrometry revealed shorter acyl chains in ceramides, and an increased proportion of sphingosine and 6-hydroxysphingosine ceramides (with C4 trans-double bond) over dihydrosphingosine and phytosphingosine ceramides in smokers, suggesting altered desaturase 1 activity. Smokers had more ordered lipid chains found by infrared spectroscopy. In conclusion, cigarette smoking perturbs the homeostasis of the barrier proteins and lipids even at a site not directly exposed to smoke.
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