ArticleNature communications2023
Manipulating microRNA miR408 enhances both biomass yield and saccharification efficiency in poplar.
Article in Nature communications, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 60 citations in OpenAlex.
- Non-coding RNA: a new perspective on the regulation of secondary metabolites in medicinal plants.Molecular horticulture · 2026Review
- Synergistic regulation of abiotic stress adaptation by copper miRNAs miR398 and miR408 in melon.The Plant journal : for cell and molecular biology · 2026Article
- miR408-5p and miR408-3p cooperatively reduce cadmium uptake and accumulation in rice.PLoS biology · 2026Article
- Genome-Wide Identification and Expression Profiling of the SPL Gene Family inPlants (Basel, Switzerland) · 2026Article
- Photoluminescence Properties of Lignin With a Genetically Introduced Luminophore in a Transgenic Hybrid Aspen That Overproduces Feruloyl-CoA 6'-Hydroxylase.Plant biotechnology journal · 2026Article
- MicroRNA-mediated regulation of cell wall dynamics and intercellular communication under stress.Frontiers in plant science · 2026Review
- Allopolyploidization-driven short-term evolution of miRNAs in Brassica A genome.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2025Article
- The MsNAC73-MsMPK3 Complex Modulates Salt Tolerance and Shoot Branching of Alfalfa via Activating MsPG2 and MsPAE12 Expressions.Plant biotechnology journal · 2025Article
- The Epigenetic Regulation of Agronomic Traits and Environmental Adaptability in Brassicas.Plant, cell & environment · 2025Review
- Advances of Long Non-Coding RNA in Perennial Plants: Development and Stress Responses.Plants (Basel, Switzerland) · 2025Review
- PagMIR166c targets PagECH2 to regulate cambial differentiation into secondary xylem, cell expansion, and lignin deposition via different auxin signaling pathways in poplar stems.The New phytologist · 2025Article
- The Role of MicroRNA-Based Strategies in Optimizing Plant Biomass Composition for Bio-Based Packaging Materials.Plants (Basel, Switzerland) · 2025Review
- Integrative analyses reveal Bna-miR397a-BnaLAC2 as a potential modulator of low-temperature adaptability in Brassica napus L.Plant biotechnology journal · 2025Article
- Phase separation of the poplar microtubule-associated protein PagPCaP1a aids microtubule depolymerization in response to high salt.Science advances · 2025Article
- Genome-wide identification, transcriptional profiling, and miRNA-binding site analysis of theFrontiers in plant science · 2025Article
- XYLAN O-ACETYLTRANSFERASE 6 promotes xylan synthesis by forming a complex with IRX10 and governs wall formation in rice.The Plant cell · 2024Article
- MicroRNA analysis reveals 2 modules that antagonistically regulate xylem tracheary element development in Arabidopsis.The Plant cell · 2024Article
- A comprehensive workflow for optimizing RNA-seq data analysis.BMC genomics · 2024Article
- Enhancing iron content and growth of cucumber seedlings with MgFe-LDHs under low-temperature stress.Journal of nanobiotechnology · 2024Article
- Switching action modes of miR408-5p mediates auxin signaling in rice.Nature communications · 2024Article
Corrections and comments
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Authors and funding
27 authors at 8 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The conversion of lignocellulosic feedstocks to fermentable sugar for biofuel production is inefficient, and most strategies to enhance efficiency directly target lignin biosynthesis, with associated negative growth impacts. Here we demonstrate, for both laboratory- and field-grown plants, that expression of Pag-miR408 in poplar (Populus alba × P. glandulosa) significantly enhances saccharification, with no requirement for acid-pretreatment, while promoting plant growth. The overexpression plants show increased accessibility of cell walls to cellulase and scaffoldin cellulose-binding modules. Conversely, Pag-miR408 loss-of-function poplar shows decreased cell wall accessibility. Overexpression of Pag-miR408 targets three Pag-LACCASES, delays lignification, and modestly reduces lignin content, S/G ratio and degree of lignin polymerization. Meanwhile, the LACCASE loss of function mutants exhibit significantly increased growth and cell wall accessibility in xylem. Our study shows how Pag-miR408 regulates lignification and secondary growth, and suggest an effective approach towards enhancing biomass yield and saccharification efficiency in a major bioenergy crop.
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