Evidence map›Paper›PMID 37463886›Full record

ArticleCancer biology & therapy2023

Identification of USP29 as a key regulator of nucleotide biosynthesis in neuroblastoma through integrative analysis of multi-omics data.

Ye Kang, Yahuan Yu, Yijia Liu, Yiwen Pan, Ru Zhang, Doudou Ren, Zeqiong Cai, Junpeng Ma, Xiaofan Xiong, Qi Zhang and 2 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cancer biology & therapy, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.6field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 1 country.

Ye KangDepartment of Cancer Precision Medicine, the MED-X Institute, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.
Yahuan YuDepartment of Nephrology, The Affiliated Hospital of Qingdao University, Qingdao, China.
Yijia LiuPrecision Medicine Center, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.
Yiwen PanPrecision Medicine Center, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.
Ru ZhangDepartment of Cancer Precision Medicine, the MED-X Institute, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.
Doudou RenDepartment of Cancer Precision Medicine, the MED-X Institute, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.
Zeqiong CaiDepartment of Cancer Precision Medicine, the MED-X Institute, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.
Junpeng MaPrecision Medicine Center, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.
Xiaofan XiongPrecision Medicine Institute, Western China Science and Technology Innovation Harbor, Xi'an, China.
Qi ZhangDepartment of Emergency Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Chengsheng ZhangDepartment of Cancer Precision Medicine, the MED-X Institute, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.
Rongfu TuDepartment of Cancer Precision Medicine, the MED-X Institute, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.ORCID 0000-0003-4484-3176
First Affiliated Hospital of Xi'an Jiaotong University · CNNanchang University · CNQingdao University · CNUnion Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cancer cells show enhanced nucleotide biosynthesis, which is essential for their unlimited proliferation, but the underlying mechanisms are not entirely clear. Ubiquitin specific peptidase 29 (USP29) was reported to sustain neuroblastoma progression by promoting glycolysis and glutamine catabolism; however, its potential role in regulating nucleotide biosynthesis in tumor cells remains unknown. In this study, we depleted endogenous USP29 in

Indexed as

MultiomicsNeuroblastomaCell Line, TumorGene Expression Regulation, NeoplasticGlucoseGlycolysisHumansN-Myc Proto-Oncogene ProteinRNA, Guide, CRISPR-Cas SystemsUbiquitin-Specific ProteasesGlucoseN-Myc Proto-Oncogene ProteinRNA, Guide, CRISPR-Cas SystemsUbiquitin-Specific ProteasesUSP29 protein, humancancer metabolismneuroblastomanucleotide biosynthesisUSP29

Identifiers

PMID37463886
PMCPMC10355683
OpenAlexW4384663131

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.