ArticleBMJ mental health2023
Cause-specific excess mortality after first diagnosis of bipolar disorder: population-based cohort study.
Article in BMJ mental health, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 20 citations in OpenAlex.
- Medicine Use Preceding Fatal Poisonings Among Individuals With Bipolar Disorder.Basic & clinical pharmacology & toxicology · 2026Article
- Allostatic and Circadian Drives in Patients with Bipolar Disorder in Depressive Episodes or with Post-Traumatic Stress Disorder Versus Healthy Controls: Neuroendocrine Comparison Through Cortisol and 6-Sulfatoxymelatonin Overnight Urine Excretion.International journal of molecular sciences · 2026Article
- Time Trends in Excess Mortality Among Individuals With Bipolar Disorder in Finland, 2000-2023: A Nationwide Register Study.Bipolar disorders · 2026Article
- Acid accumulation in bipolar disorder.Journal of affective disorders · 2026Article
- Bipolar Disorder and Poisoning due to Medicines or Illegal Substances.Acta psychiatrica Scandinavica · 2025Article
- Bipolar disorder.Lancet (London, England) · 2025Review
- Machine learning-based mortality risk assessment in first-episode bipolar disorder: a transdiagnostic external validation study.EClinicalMedicine · 2025Article
- Are Adults With Bipolar Disorder at Increased Cardiovascular Risk due to Their Physical, Biochemical, and Physiological Profiles? The FINEXT-BD Study.Brain and behavior · 2025Article
- Mapping review of register-based cohort studies of bipolar disorder.Bipolar disorders · 2024Review
- Mortality risk and mood stabilizers in bipolar disorder: a propensity-score-weighted population-based cohort study in 2002-2018.Epidemiology and psychiatric sciences · 2024Article
Corrections and comments
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Authors and funding
7 authors at 4 institutions in 4 countries.
Funding
Abstract
backgroundBipolar disorder (BD) is associated with increased mortality, but evidence on cause-specific mortality is limited.
objectiveTo investigate cause-specific premature excess mortality in BD.
methodsFinnish nationwide cohort study of individuals with and without a diagnosis of BD who were aged 15-64 years during 2004-2018. Standardised mortality ratios (SMRs) with 95% CIs were calculated for BD using the mortality rates in the Finnish general population without BD as weights. Causes of death were defined by the International Classification of Diseases, 10th revision codes.
findingsOf the included 47 018 individuals with BD, 3300 (7%) died during follow-up. Individuals with BD had sixfold higher mortality due to external causes (SMR: 6.01, 95% CI: 5.68, 6.34) and twofold higher mortality due to somatic causes (SMR: 2.06, 95% CI: 1.97, 2.15). Of the deaths due to external causes, 83% (1061/1273) were excess deaths, whereas 51% (1043/2027) of the deaths due to somatic causes were excess. About twice the number of potential years of life were lost in excess due to external causes than due to somatic causes. Alcohol-related causes contributed more to excess mortality than deaths due to cardiovascular disease.
conclusionExternal causes of death contributed more to the mortality gap than somatic causes after controlling for age-specific background general population mortality. CLINICAL IMPLICATION: A balanced consideration between therapeutic response, different treatment options and risk of cause-specific mortality is needed to prevent premature mortality in BD and to reduce the mortality gap.
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