Evidence map›Paper›PMID 37463635›Full record

ReviewFree radical biology & medicine2023

Vitamin E discussion forum position paper on the revision of the nomenclature of vitamin E.

Angelo Azzi, Jeffrey Atkinson, Nesrin Kartal Ozer, Danny Manor, Maria Wallert, Francesco Galli

Open access · hybridAbstract readReviewConsensus Statement
In one paragraph

Review in Free radical biology & medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
2.5field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 23 citations in OpenAlex.

  1. Trial
  2. Review
  3. Review
  4. Article
  5. Potential Vitamin E Signaling Mediators in Skeletal Muscle.Antioxidants (Basel, Switzerland) · 2024
    Review
  6. Article
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 6 institutions in 5 countries.

Angelo AzziSchool of Graduate Biomedical Pharmacology and Drug Development Program, Tufts University, Boston, MA, USA. Electronic address: angelo.azzi@tufts.edu.
Jeffrey AtkinsonDepartment of Chemistry and Centre for Biotechnology, Brock University, St. Catharines, L2S3A1, Ontario, Canada.
Nesrin Kartal OzerDepartment of Biochemistry, Faculty of Medicine, Uskudar University, 34662, Uskudar, Istanbul, Turkey.
Danny ManorDepartment of Nutrition, School of Medicine, Case Western Reserve University, 44106, Cleveland, OH, USA.
Maria WallertBiochemistry and Physiology of Nutrition, Institute of Nutritional Science, Friedrich Schiller University, Jena, Germany.
Francesco GalliHuman Nutrition and Nutrigenomics Lab, Dept of Pharmaceutical Sciences, University of Perugia, 06122, Perugia, Italy. Electronic address: francesco.galli@unipg.it.
Brock University · CACase Western Reserve University · USFriedrich Schiller University Jena · DETufts University · USUniversity of Perugia · ITÜsküdar University · TR

Funding

Functions of vitamin E and the tocopherol transfer proteinR01DK125115 · NIDDK · CASE WESTERN RESERVE UNIVERSITY · PI MANOR, DANNY · 2021 to 2024
$2.6M
NIDDK NIH HHS R01 DK125115
6 · The paper itself

Abstract

This position paper opens a discussion forum of this Journal dedicated to a scientific debate on Vitamin E nomenclature. With this article we provide the scientific and medical communities with what we consider relevant information in favor of revising the nomenclature of vitamin E. To our knowledge, only RRR-α-tocopherol has been medically used to protect against a deficiency disease in humans, and therefore, it would be appropriate to restrict the term vitamin to this molecule. The direct demonstration of a vitamin function to other tocochromanols (including other tocopherols, tocotrienols and eventually tocomonoenols), has not yet been scientifically shown. In fact, the medical prescription of a molecule against the deficiency disease only because it has been included in the "Vitamin E family", but not tested as vitamin E, could lead to ineffective therapy and potentially dangerous consequences for patients. The idea of this revision launched during the recent 3rd Satellite Symposium on Vitamin E of the 2022 SFRR-Europe meeting, offers a open platform of discussion for the scientists involved in vitamin E research and scientific societies interested to this subject.

Indexed as

TocotrienolsVitamin EAntioxidantsHumansTocopherolsVitaminsAntioxidantsTocopherolsTocotrienolsVitamin EVitaminsAVEDnomenclaturenutritionRRR-α-tocopheroltocomonoenolstocopherolstocotrienolsvitamin E

Identifiers

PMID37463635
PMCPMC10681751
OpenAlexW4384470443

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.