Evidence map›Paper›PMID 37463580›Full record

ReviewNeuron2023

Synaptic and circuit functions of multitransmitter neurons in the mammalian brain.

Michael L Wallace, Bernardo L Sabatini

Open access · bronzeAbstract readReview
In one paragraph

Review in Neuron, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed
8.6field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 58 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

Michael L WallaceDepartment of Anatomy and Neurobiology, Boston University Chobanian & Avedisian School of Medicine, Boston, MA, USA. Electronic address: mlwall12@bu.edu.
Bernardo L SabatiniHoward Hughes Medical Institute, Department of Neurobiology, Harvard Medical School, Boston, MA, USA.
Boston University · USHoward Hughes Medical Institute · US

Funding

Serotonergic modulation of the circuits and cell-types of the lateral habenulaR01MH133608 · NIMH · BOSTON UNIVERSITY MEDICAL CAMPUS · PI Michael L Wallace · 2023 to 2026
$2.4M
Structure and function of the mouse parafasicular and entopeduncular nucleiR01NS103226 · NINDS · HARVARD MEDICAL SCHOOL · PI OSTEN, PAVEL, SABATINI, BERNARDO L · 2017 to 2021
$2.1M
A Function for the Entopeduncular Nucleus in Motivated BehaviorR00NS105883 · NINDS · BOSTON UNIVERSITY MEDICAL CAMPUS · PI WALLACE, MICHAEL L · 2021 to 2023
$744k
NIMH NIH HHS R01 MH133608NINDS NIH HHS R00 NS105883NINDS NIH HHS R01 NS103226
6 · The paper itself

Abstract

Neurons in the mammalian brain are not limited to releasing a single neurotransmitter but often release multiple neurotransmitters onto postsynaptic cells. Here, we review recent findings of multitransmitter neurons found throughout the mammalian central nervous system. We highlight recent technological innovations that have made the identification of new multitransmitter neurons and the study of their synaptic properties possible. We also focus on mechanisms and molecular constituents required for neurotransmitter corelease at the axon terminal and synaptic vesicle, as well as some possible functions of multitransmitter neurons in diverse brain circuits. We expect that these approaches will lead to new insights into the mechanism and function of multitransmitter neurons, their role in circuits, and their contribution to normal and pathological brain function.

Indexed as

NeuronsSynaptic TransmissionAnimalsBrainCentral Nervous SystemGlutamic AcidMammalsNeurotransmitter AgentsGlutamic AcidNeurotransmitter Agentsacetylcholineco-packagingcoreleasecotransmissiondopamineGABAglutamatemultitransmitterserotonin

Identifiers

PMID37463580
PMCPMC10592565
OpenAlexW4384564286

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.