Evidence map›Paper›PMID 37463214›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2023

Small mitochondrial protein NERCLIN regulates cardiolipin homeostasis and mitochondrial ultrastructure.

Svetlana Konovalova, Rubén Torregrosa-Muñumer, Pooja Manjunath, Xiaonan Liu, Sundar Baral, Kaneez Fatima, Minna Holopainen, Jouni Kvist, Jayasimman Rajendran, Yang Yang and 4 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.6field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 4 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 1 institution in 2 countries.

Svetlana KonovalovaStem Cells and Metabolism Research Program, Research Programs Unit, Faculty of Medicine, University of Helsinki, 00014 Helsinki, Finland.
Rubén Torregrosa-MuñumerStem Cells and Metabolism Research Program, Research Programs Unit, Faculty of Medicine, University of Helsinki, 00014 Helsinki, Finland.
Pooja ManjunathStem Cells and Metabolism Research Program, Research Programs Unit, Faculty of Medicine, University of Helsinki, 00014 Helsinki, Finland.
Xiaonan LiuInstitute of Biotechnology, Helsinki Institute of Life Science, University of Helsinki, 00014 Helsinki, Finland.ORCID 0000-0002-9600-0536
Sundar BaralStem Cells and Metabolism Research Program, Research Programs Unit, Faculty of Medicine, University of Helsinki, 00014 Helsinki, Finland.
Kaneez FatimaInstitute of Biotechnology, Helsinki Institute of Life Science, University of Helsinki, 00014 Helsinki, Finland.ORCID 0000-0003-2519-7754
Minna HolopainenMolecular and Integrative Biosciences Research Program, Faculty of Biological and Environmental Sciences, University of Helsinki, 00014 Helsinki, Finland.ORCID 0000-0002-3030-8677
Jouni KvistStem Cells and Metabolism Research Program, Research Programs Unit, Faculty of Medicine, University of Helsinki, 00014 Helsinki, Finland.ORCID 0000-0002-4089-8877
Jayasimman RajendranStem Cells and Metabolism Research Program, Research Programs Unit, Faculty of Medicine, University of Helsinki, 00014 Helsinki, Finland.
Yang YangStem Cells and Metabolism Research Program, Research Programs Unit, Faculty of Medicine, University of Helsinki, 00014 Helsinki, Finland.
Markku VarjosaloInstitute of Biotechnology, Helsinki Institute of Life Science, University of Helsinki, 00014 Helsinki, Finland.
Reijo KäkeläMolecular and Integrative Biosciences Research Program, Faculty of Biological and Environmental Sciences, University of Helsinki, 00014 Helsinki, Finland.ORCID 0000-0003-4953-3062
Pentti SomerharjuHelsinki University Lipidomics Unit, Helsinki Institute of Life Science and Biocenter Finland, University of Helsinki, 00014 Helsinki, Finland.ORCID 0000-0003-0623-7538
Henna TyynismaaStem Cells and Metabolism Research Program, Research Programs Unit, Faculty of Medicine, University of Helsinki, 00014 Helsinki, Finland.ORCID 0000-0002-2493-2422
University of Helsinki · FI

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cardiolipin (CL) is an essential phospholipid for mitochondrial structure and function. Here, we present a small mitochondrial protein, NERCLIN, as a negative regulator of CL homeostasis and mitochondrial ultrastructure. Primate-specific NERCLIN is expressed ubiquitously from the

Indexed as

CardiolipinsMitochondrial ProteinsAnimalsHomeostasisMitochondriaMitochondrial MembranesCardiolipinsMitochondrial ProteinscardiolipinNERCLINOPA1prohibitinssmall mitochondrial proteins

Identifiers

PMID37463214
PMCPMC10372682
OpenAlexW4384663496

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.