Evidence map›Paper›PMID 37463201›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2023

The role of

Arne Alder, Cecilia P Sanchez, Matthew R G Russell, Lucy M Collinson, Michael Lanzer, Michael J Blackman, Tim-Wolf Gilberger, Joachim M Matz

Open access · hybridAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
5.8field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 20 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Lysosome as a Chemical Reactor.International journal of molecular sciences · 2025
    Review
  7. Chemical propulsion of hemozoin crystal motion in malaria parasites.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Review
  13. To quest new targets ofJournal of parasitic diseases : official organ of the Indian Society for Parasitology · 2024
    Review
  14. Article
  15. Inducing indigestion in malaria parasites: Genetic manipulations of a proton pump.Proceedings of the National Academy of Sciences of the United States of America · 2023
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 2 countries.

Arne AlderCell Biology of Human Parasites Group, Centre for Structural Systems Biology, Hamburg 22607, Germany.ORCID 0000-0003-4918-4640
Cecilia P SanchezCenter of Infectious Diseases, Parasitology, Heidelberg University Hospital, Heidelberg 69120, Germany.ORCID 0000-0002-3334-3726
Matthew R G RussellElectron Microscopy Science Technology Platform, The Francis Crick Institute, London NW1 1AT, United Kingdom.ORCID 0000-0003-4608-7669
Lucy M CollinsonElectron Microscopy Science Technology Platform, The Francis Crick Institute, London NW1 1AT, United Kingdom.ORCID 0000-0003-0260-613X
Michael LanzerCenter of Infectious Diseases, Parasitology, Heidelberg University Hospital, Heidelberg 69120, Germany.
Michael J BlackmanMalaria Biochemistry Laboratory, The Francis Crick Institute, London NW1 1AT, United Kingdom.ORCID 0000-0002-7442-3810
Tim-Wolf GilbergerCell Biology of Human Parasites Group, Centre for Structural Systems Biology, Hamburg 22607, Germany.
Joachim M MatzCell Biology of Human Parasites Group, Centre for Structural Systems Biology, Hamburg 22607, Germany.ORCID 0000-0002-0575-0412
The Francis Crick Institute · GBHeidelberg University · DEUniversität Hamburg · DEKing's College London · GB

Funding

Wellcome Trust CC2129
6 · The paper itself

Abstract

To ensure their survival in the human bloodstream, malaria parasites degrade up to 80% of the host erythrocyte hemoglobin in an acidified digestive vacuole. Here, we combine conditional reverse genetics and quantitative imaging approaches to demonstrate that the human malaria pathogen

Indexed as

AntimalarialsMalaria, FalciparumParasitesAdenosine TriphosphatasesAnimalsHumansPlasmodium falciparumVacuolesAdenosine TriphosphatasesAntimalarialschloroquinemalariaPlasmodium falciparumvacuoleV-ATPase

Identifiers

PMID37463201
PMCPMC10372686
OpenAlexW4384665185

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.