Evidence map›Paper›PMID 37463061›Full record

ArticleJournal of neurotrauma2024

CARE4Kids Study: Endophenotypes of Persistent Post-Concussive Symptoms in Adolescents: Study Rationale and Protocol.

Christopher C Giza, Gerard Gioia, Lawrence J Cook, Robert Asarnow, Aliyah Snyder, Talin Babikian, Paul Thompson, Jeffery J Bazarian, Christopher T Whitlow, Christopher M Miles and 13 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of neurotrauma, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.5field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Article
  3. Prognostic Utility of Immediate Memory and Delayed Recall Assessments for Adolescent Concussion.Clinical journal of sport medicine : official journal of the Canadian Academy of Sport Medicine · 2025
    Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

23 authors at 11 institutions in 1 country.

Christopher C GizaDepartment of Neurology, UCLA School of Medicine, University of California Los Angeles, Los Angeles, California, USA.
Gerard GioiaDepartment of Neuropsychology, Children's National Hospital and George Washington University School of Medicine, Washington, DC, USA.
Lawrence J CookDepartment of Pediatric Critical Care, University of Utah, Salt Lake City, Utah, USA.
Robert AsarnowDepartment of Psychiatry and Biobehavioral Sciences, UCLA School of Medicine, University of California Los Angeles, Los Angeles, California, USA.
Aliyah SnyderUCLA BrainSPORT Program, Los Angeles, California, USA.
Talin BabikianDepartment of Psychiatry and Biobehavioral Sciences, UCLA School of Medicine, University of California Los Angeles, Los Angeles, California, USA.
Paul ThompsonDepartments of Ophthalmology, Neurology, Psychiatry and the Behavioral Sciences, and Radiology and Engineering, University of Southern California, Los Angeles, California, USA.
Jeffery J BazarianDepartment of Emergency Medicine, University of Rochester School of Medicine and Dentistry, Rochester, New York, USA.
Christopher T WhitlowDepartment of Radiology, Wake Forest University School of Medicine, Atrium Health Wake Forest Baptist, Winston-Salem, North Carolina, USA.
Christopher M MilesDepartment of Family and Community Medicine, Wake Forest University School of Medicine, Atrium Health Wake Forest Baptist, Winston-Salem, North Carolina, USA.
Scott OtallahDepartment of Neurology, Wake Forest University School of Medicine, Atrium Health Wake Forest Baptist, Winston-Salem, North Carolina, USA.
Joshua KaminsDepartment of Neurology, UCLA School of Medicine, University of California Los Angeles, Los Angeles, California, USA.
Nyaz DidehbaniDepartment of Psychiatry, University of Texas Southwestern Medical Center, Dallas, Texas, USA.
Philip E RosenbaumDepartment of Neurosurgery, UCLA School of Medicine, University of California Los Angeles, Los Angeles, California, USA.
Sara P D ChrismanDepartment of Pediatrics, University of Washington School of Medicine University of Washington, Seattle, Washington, USA.
Christopher G VaughanDepartment of Neuropsychology, Children's National Hospital and George Washington University School of Medicine, Washington, DC, USA.
Munro CullumDepartment of Psychiatry, University of Texas Southwestern Medical Center, Dallas, Texas, USA.
David M PopoliDepartment of Orthopedics and Rehabilitation, Wake Forest University School of Medicine, Atrium Health Wake Forest Baptist, Winston-Salem, North Carolina, USA.
Meeryo ChoeDepartment of Pediatric Neurology, UCLA School of Medicine, University of California Los Angeles, Los Angeles, California, USA.
Jessica GillSchool of Nursing, Johns Hopkins University, Baltimore, Maryland, USA.
Emily L DennisTBI and Concussion Center, University of Utah, Salt Lake City, Utah, USA.
Christine L Mac DonaldDepartment of Neurological Surgery, University of Washington School of Medicine University of Washington, Seattle, Washington, USA.
Frederick P RivaraDepartment of Pediatrics, University of Washington School of Medicine University of Washington, Seattle, Washington, USA.
University of California, Los Angeles · USAtrium Health Wake Forest Baptist · USGeorge Washington University Hospital · USSeattle Children's Hospital · USThe University of Texas Southwestern Medical Center · USUniversity of Utah · USJohns Hopkins University · USUniversity of Florida Health · USUniversity of Rochester · USUniversity of Southern California · USUniversity of Washington · US

Funding

Endophenotypes of Persistent Post-Concussive Symptoms in Adolescents: CARE4KidsU54NS121688 · NINDS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI LAWRENCE Joseph COOK · 2021 to 2026
$18.7M
NINDS Biomarker RepositoryU24NS095871 · NINDS · INDIANA UNIVERSITY INDIANAPOLIS · PI TATIANA M. FOROUD · 2015 to 2026
$18.3M
Timing Of Exercise In Concussed Rat AthletesR01NS110757 · NINDS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI PRINS, MAYUMI LYNN · 2019 to 2023
$2.4M
NINDS NIH HHS R01 NS110757NINDS NIH HHS U24 NS095871NINDS NIH HHS U54 NS121688
6 · The paper itself

Abstract

Treatment of youth concussion during the acute phase continues to evolve, and this has led to the emergence of guidelines to direct care. While symptoms after concussion typically resolve in 14-28 days, a portion (∼20%) of adolescents endorse persistent post-concussive symptoms (PPCS) beyond normal resolution. This report outlines a study implemented in response to the National Institute of Neurological Diseases and Stroke call for the development and initial clinical validation of objective biological measures to predict risk of PPCS in adolescents. We describe our plans for recruitment of a Development cohort of 11- to 17-year-old youth with concussion, and collection of autonomic, neurocognitive, biofluid, and imaging biomarkers. The most promising of these measures will then be validated in a separate Validation cohort of youth with concussion, and a final, clinically useful algorithm will be developed and disseminated. Upon completion of this study, we will have generated a battery of measures predictive of high risk for PPCS, which will allow for identification and testing of interventions to prevent PPCS in the most high-risk youth.

Indexed as

Brain ConcussionPost-Concussion SyndromeAdolescentChildEndophenotypesHumansadolescentautonomic nervous systembiomarkerbloodendophenotypeMRIpersistent post-concussion symptoms

Identifiers

PMID37463061
PMCPMC11071085
OpenAlexW4384662811

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.