Evidence map›Paper›PMID 37462840›Full record

ArticleDiabetes therapy : research, treatment and education of diabetes and related disorders2023

Sex Hormone Binding Globulin is an Independent Predictor for Insulin Resistance in Male Patients with Newly Diagnosed Type 2 Diabetes Mellitus.

Rong Huang, Ying Wang, Rengna Yan, Bo Ding, Jianhua Ma

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Diabetes therapy : research, treatment and education of diabetes and related disorders, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Rong Huang *Department of Endocrinology, Nanjing First Hospital, Nanjing Medical University, No.32 Gongqingtuan Road, Nanjing, 210012, China.
Ying Wang *Department of Endocrinology, Nanjing First Hospital, Nanjing Medical University, No.32 Gongqingtuan Road, Nanjing, 210012, China.
Rengna Yan *Department of Endocrinology, Nanjing First Hospital, Nanjing Medical University, No.32 Gongqingtuan Road, Nanjing, 210012, China.
Bo DingDepartment of Endocrinology, Nanjing First Hospital, Nanjing Medical University, No.32 Gongqingtuan Road, Nanjing, 210012, China. dingbonanjing@sina.com.
Jianhua MaDepartment of Endocrinology, Nanjing First Hospital, Nanjing Medical University, No.32 Gongqingtuan Road, Nanjing, 210012, China. majianhua196503@126.com.ORCID http://orcid.org/0000-0001-9383-2559

Funding

Key Technology Research and Development Program of Shandong 2018YFC1314100Nanjing Medical Science and Technology Development Fund ZKX22038
6 · The paper itself

Abstract

introductionThis study explored the correlation between sex hormones, sex hormone binding globulin (SHBG), and insulin resistance in male patients with newly diagnosed type 2 diabetes mellitus (T2DM).

methodsA total of 48 male patients with newly diagnosed T2DM were enrolled in this study between March 2022 and December 2022. Clinical characteristics, sex hormones, and SHBG levels were collected. All enrolled subjects received intensive hypoglycemic treatment with insulin pump for 1 week to achieve glycemic control, then the steady-state glucose infusion rate (GIR), an indicator of insulin sensitivity, was determined by the hyperinsulinemic-euglycemic clamp. Correlation analysis and multivariate logistic regression analysis were performed to explore the association of clinical characteristics, sex hormones, and SHBG with insulin sensitivity. The optimal cutoff value to predict insulin resistance was calculated using receiver operating characteristic (ROC) curve.

resultsAccording to the GIR cut-point value of 5.700 mg/(kg min), there were 40 patients with insulin resistance (IR group) and 8 patients without (non-IR group). The IR group exhibited lower testosterone and SHBG levels than the non-IR group (all p < 0.050). Correlation analysis showed that insulin sensitivity was positively associated with testosterone and SHBG, while negatively associated with body mass index, fasting blood glucose, alanine aminotransferase, aspartate aminotransferase, total cholesterol, triglyceride, and apolipoprotein B (all p < 0.050). Multivariate logistic regression analysis demonstrated that SHBG is an independent predictor for insulin resistance (p = 0.029). Further ROC curve analysis revealed that the optimal cutoff value of SHBG to predict insulin resistance is 17.200 nmol/L, with the corresponding area under the curve (AUC) and its 95% confidence interval (CI) being 0.813 and 0.691-0.934.

conclusionsSHBG is an independent predictor for insulin resistance in male patients with newly diagnosed T2DM. TRIAL REGISTRATION NUMBER: KY20220314-01.

Indexed as

Hyperinsulinemic-euglycemic clampInsulin resistanceSex hormone binding globulinType 2 diabetes mellitus

Identifiers

PMID37462840
PMCPMC10499719

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.