Evidence map›Paper›PMID 37462760›Full record

ArticleVirchows Archiv : an international journal of pathology2024

Programmed death-ligand 1 and tumor-infiltrating lymphocytes (TILs) - low TIL density may predict poorer long-term prognosis in T1 laryngeal cancer.

Pihla Pakkanen, Taru Ilmarinen, Elina Halme, Heikki Irjala, Petri Koivunen, Matti Pukkila, Sami Ventelä, Alhadi Almangush, Eva-Maria Birkman, Outi Lindgren and 5 more

Erratum issuedAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Virchows Archiv : an international journal of pathology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
  4. Article
  5. Article
  6. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

15 authors.

Pihla PakkanenDepartment of Otorhinolaryngology - Head and Neck Surgery, University of Helsinki and Helsinki University Hospital, Helsinki, Finland. pihla.pakkanen@helsinki.fi.ORCID http://orcid.org/0000-0002-0009-8146
Taru IlmarinenDepartment of Otorhinolaryngology - Head and Neck Surgery, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.
Elina HalmeDepartment of Otorhinolaryngology - Head and Neck Surgery, University of Tampere and Tampere University Hospital, Tampere, Finland.
Heikki IrjalaDepartment of Otorhinolaryngology - Head and Neck Surgery, University of Turku and Turku University Hospital, Turku, Finland.
Petri KoivunenDepartment of Otorhinolaryngology - Head and Neck Surgery, University of Oulu and Oulu University Hospital, Oulu, Finland.
Matti PukkilaDepartment of Otorhinolaryngology - Head and Neck Surgery, University of Eastern Finland and Kuopio University Hospital, Kuopio, Finland.
Sami VenteläDepartment of Otorhinolaryngology - Head and Neck Surgery, University of Turku and Turku University Hospital, Turku, Finland.
Alhadi AlmangushDepartment of Pathology, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.
Eva-Maria BirkmanDepartment of Pathology, University of Turku and Turku University Hospital, Turku, Finland.
Outi LindgrenDepartment of Pathology, University of Oulu and Oulu University Hospital, Oulu, Finland.
Virva PohjolainenFimlab Laboratories, Department of Pathology, Tampere University Hospital, Tampere, Finland.
Nelli SjöblomDepartment of Pathology, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.
Caj HaglundDepartment of Pathology, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.
Jaana HagströmDepartment of Pathology, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.
Leena-Maija AaltonenDepartment of Otorhinolaryngology - Head and Neck Surgery, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We evaluated the prognostic role of programmed death-ligand 1 (PD-L1) and tumor-infiltrating lymphocytes (TILs) in T1 glottic laryngeal squamous cell carcinoma (LSCC). T1 glottic LSCC patients (n = 174) treated at five Finnish university hospitals between 2003 and 2013 were included. Tissue microarray (TMA) blocks were used for PD-L1 immunohistochemistry. TILs were scored from intratumoral and stromal regions in whole tissue sections. Of 174 patients, 92 (53%) had negative, 66 (38%) intermediate, and 16 (9%) high PD-L1 levels. Of 80 patients whose TILs were analyzed, 50 (63%) had low and 30 (38%) high stromal TIL density. Patients with a local recurrence or a new primary tumor of the larynx had lower TIL density than had other patients (p = 0.047). High PD-L1 expression with low stromal TIL density was associated with inferior 5-year disease-specific survival (85% vs. 100%, p = 0.02). In conclusion, in patients treated for T1 glottic LSCC, low stromal TIL density was associated with local recurrences and new primary tumors of the larynx. High PD-L1 expression with low stromal TIL density may be associated with worse survival in T1 glottic LSCC.

Indexed as

B7-H1 AntigenLaryngeal NeoplasmsLymphocytes, Tumor-InfiltratingAdultAgedAged, 80 and overBiomarkers, TumorCarcinoma, Squamous CellFemaleHumansImmunohistochemistryMaleMiddle AgedNeoplasm Recurrence, LocalPrognosisSquamous Cell Carcinoma of Head and NeckB7-H1 AntigenBiomarkers, TumorCD274 protein, humanEarly laryngeal cancerPrognosisProgrammed death-ligand 1T1 glottic cancerTumor-infiltrating lymphocytes

Identifiers

PMID37462760
PMCPMC11329626

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.