Evidence map›Paper›PMID 37462752›Full record

ArticleJournal of neurology2023

Longitudinal changes in qualitative aspects of semantic fluency in presymptomatic and prodromal genetic frontotemporal dementia.

Lize C Jiskoot, Esther van den Berg, Sascha A A M Laenen, Jackie M Poos, Lucia A A Giannini, Djaina D Satoer, Judy van Hemmen, Yolande A L Pijnenburg, Jet M J Vonk, Harro Seelaar

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of neurology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 2 pooled it
1.1field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 2 syntheses or guidelines pooled it, 5 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 3 countries.

Lize C JiskootDepartment of Neurology and Alzheimer Center Erasmus MC, Erasmus MC University Medical Center, Room NF-331, Post Box 2040, 3000 CA, Rotterdam, The Netherlands. l.c.jiskoot@erasmusmc.nl.ORCID http://orcid.org/0000-0002-1120-1858
Esther van den BergDepartment of Neurology and Alzheimer Center Erasmus MC, Erasmus MC University Medical Center, Room NF-331, Post Box 2040, 3000 CA, Rotterdam, The Netherlands.
Sascha A A M LaenenDepartment of Neurology and Alzheimer Center Erasmus MC, Erasmus MC University Medical Center, Room NF-331, Post Box 2040, 3000 CA, Rotterdam, The Netherlands.
Jackie M PoosDepartment of Neurology and Alzheimer Center Erasmus MC, Erasmus MC University Medical Center, Room NF-331, Post Box 2040, 3000 CA, Rotterdam, The Netherlands.
Lucia A A GianniniDepartment of Neurology and Alzheimer Center Erasmus MC, Erasmus MC University Medical Center, Room NF-331, Post Box 2040, 3000 CA, Rotterdam, The Netherlands.
Djaina D SatoerDepartment of Neurosurgery, Erasmus University Medical Center, Rotterdam, The Netherlands.
Judy van HemmenDepartment of Neurology and Alzheimer Center Erasmus MC, Erasmus MC University Medical Center, Room NF-331, Post Box 2040, 3000 CA, Rotterdam, The Netherlands.
Yolande A L PijnenburgAlzheimer Center Amsterdam, Amsterdam University Medical Center, Amsterdam, The Netherlands.
Jet M J VonkMemory and Aging Center, Department of Neurology, University of California, San Francisco, CA, USA.
Harro SeelaarDepartment of Neurology and Alzheimer Center Erasmus MC, Erasmus MC University Medical Center, Room NF-331, Post Box 2040, 3000 CA, Rotterdam, The Netherlands.
Erasmus MC · NLAmsterdam University Medical Centers · NLUniversity of California, San Francisco · US

Funding

ZonMw 10510032120002
6 · The paper itself

Abstract

backgroundThe semantic fluency test is one of the most widely used neuropsychological tests in dementia diagnosis. Research utilizing the qualitative, psycholinguistic information embedded in its output is currently underexplored in presymptomatic and prodromal genetic FTD.

methodsPresymptomatic MAPT (n = 20) and GRN (n = 43) mutation carriers, and controls (n = 55) underwent up to 6 years of neuropsychological assessment, including the semantic fluency test. Ten mutation carriers became symptomatic (phenoconverters). Total score and five qualitative fluency measures (lexical frequency, age of acquisition, number of clusters, cluster size, number of switches) were calculated. We used multilevel linear regression modeling to investigate longitudinal decline. We assessed the co-correlation of the qualitative measures at each time point with principal component analysis. We explored associations with cognitive decline and grey matter atrophy using partial correlations, and investigated classification abilities using binary logistic regression.

resultsThe interrater reliability of the qualitative measures was good (ICC = 0.75-0.90). There was strong co-correlation between lexical frequency and age of acquisition, and between clustering and switching. At least 4 years pre-phenoconversion, GRN phenoconverters had fewer but larger clusters (p < 0.001), and fewer switches (p = 0.004), correlating with lower executive function (r = 0.87-0.98). Fewer switches was predictive of phenoconversion, correctly classifying 90.3%. Starting at least 4 years pre-phenoconversion, MAPT phenoconverters demonstrated an increase in lexical frequency (p = 0.009) and a decline in age of acquisition (p = 0.034), correlating with lower semantic processing (r = 0.90). Smaller cluster size was predictive of phenoconversion, correctly classifying 89.3%. Increase in lexical frequency and decline in age of acquisition were associated with grey matter volume loss of predominantly temporal areas, while decline in the number of clusters, cluster size, and switches correlated with grey matter volume loss of predominantly frontal areas.

conclusionsQualitative aspects of semantic fluency could give insight into the underlying mechanisms as to why the "traditional" total score declines in the different FTD mutations. However, the qualitative measures currently demonstrate more fluctuation than the total score, the measure that seems to most reliably deteriorate with time. Replication in a larger sample of FTD phenoconverters is warranted to identify if qualitative measures could be sensitive cognitive biomarkers to identify and track mutation carriers converting to the symptomatic stage of FTD.

Indexed as

Frontotemporal DementiaC9orf72 ProteinHumansLongitudinal StudiesMutationNeuropsychological TestsReproducibility of ResultsSemanticsC9orf72 ProteinFrontotemporal dementiaNeuropsychologyPhenoconversionSemantic fluency

Identifiers

PMID37462752
PMCPMC10576727
OpenAlexW4384626461

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.