Evidence map›Paper›PMID 37462743›Full record

ArticlePediatric nephrology (Berlin, Germany)2024

Urine soluble TLR4 levels may contribute to predict urinary tract infection in children: the UTILISE Study.

Bagdagul Aksu, Alberto Caldas Afonso, Ipek Akil, Harika Alpay, Bahriye Atmis, Ozlem Aydog, Aysun Karabay Bayazıt, Meral Torun Bayram, Ilmay Bilge, Ipek Kaplan Bulut and 53 more

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Article in Pediatric nephrology (Berlin, Germany), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.4field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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3 · Its place in the literature

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1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Review
4 · The record

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5 · Who and what money

Authors and funding

63 authors at 20 institutions in 7 countries.

Bagdagul AksuDepartment of Pediatrics Basic Sciences, Institute of Child Health, Istanbul University, Istanbul, Turkey. bagdagul@yahoo.com.ORCID 0000-0003-3274-8024
Alberto Caldas AfonsoDivision of Pediatric Nephrology, Centro Materno Infantil do Norte, Centro Hospitalar Universitário do Porto, Porto, Portugal.
Ipek AkilDivision of Pediatric Nephrology, Faculty of Medicine, Celal Bayar University, Manisa, Turkey.
Harika AlpayDivision of Pediatric Nephrology, Faculty of Medicine, Marmara University, Istanbul, Turkey.
Bahriye AtmisPediatric Nephrology, Erzurum Training and Research Hospital, Erzurum, Turkey.
Ozlem AydogDivision of Pediatric Nephrology, Faculty of Medicine, Ondokuz Mayis University, Samsun, Turkey.
Aysun Karabay BayazıtDivision of Pediatric Nephrology, Faculty of Medicine, Cukurova University, Adana, Turkey.
Meral Torun BayramDivision of Pediatric Nephrology, Faculty of Medicine, Dokuz Eylul University, Izmir, Turkey.
Ilmay BilgeDivision of Pediatric Nephrology, Department of Pediatrics, School of Medicine, Koc University, Istanbul, Turkey.
Ipek Kaplan BulutDivision of Pediatric Nephrology, Faculty of Medicine, Ege University, Izmir, Turkey.
Bahar BuyukkaragozDivision of Pediatric Nephrology, Faculty of Medicine, Gazi University, Ankara, Turkey.
Elif ComakDivision of Pediatric Nephrology, Faculty of Medicine, Akdeniz University, Antalya, Turkey.
Belde Kasap DemirDivision of Pediatric Nephrology, Tepecik Training and Research Hospital, University of Health Sciences, Izmir, Turkey.
Nida DincelDivision of Pediatric Nephrology, Dr. Behcet Uz Children Diseases Training and Research Hospital, University of Health Sciences, Izmir, Turkey.
Osman DonmezDivision of Pediatric Nephrology, Faculty of Medicine, Uludag University, Bursa, Turkey.
Mehmet Akif DurmusDepartment of Medical Microbiology, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey.
Hasan DursunDivision of Pediatric Nephrology, Okmeydani Training and Research Hospital, University of Health Sciences, Istanbul, Turkey.
Ruhan DusunselDivision of Pediatric Nephrology, Faculty of Medicine, Erciyes University, Kayseri, Turkey.
Ali DuzovaDivision of Pediatric Nephrology, Hacettepe University Faculty of Medicine, Ankara, Turkey.
Pelin ErtanDivision of Pediatric Nephrology, Faculty of Medicine, Celal Bayar University, Manisa, Turkey.
Asuman GedikbasiDepartment of Rare Diseases, Institute of Child Health, Istanbul University, Istanbul, Turkey.
Nilufer GoknarDivision of Pediatric Nephrology, Bagcilar Training and Research Hospital, University of Health Sciences, Istanbul, Turkey.
Sercin GuvenDivision of Pediatric Nephrology, Faculty of Medicine, Marmara University, Istanbul, Turkey.
Duygu HacihamdiogluDivision of Pediatric Nephrology, Faculty of Medicine, Bahcesehir University, Istanbul, Turkey.
Augustina JankauskieneClinic of Pediatrics, Institute of Clinical Medicine, Vilnius University, Vilnius, Lithuania.
Mukaddes KalyoncuDivision of Pediatric Nephrology, Faculty of Medicine, Karadeniz Technic University, Trabzon, Turkey.
Salih KavukcuDivision of Pediatric Nephrology, Faculty of Medicine, Dokuz Eylul University, Izmir, Turkey.
Bahriye Uzun KenanDivision of Pediatric Nephrology, Faculty of Medicine, Gazi University, Ankara, Turkey.
Nuran KucukDivision of Pediatric Nephrology, Kartal Training and Research Hospital, Istanbul, Turkey.
Bahar KuralDepartment of Pediatrics, Health Science University Bakirkoy Sadi Konuk Training and Research Hospital, Istanbul, Turkey.
Mieczysław LitwinDivision of Nephrology, Kidney Transplantation and Hypertension, The Children's Memorial Health Institute, Warsaw, Poland.
Giovanni MontiniPediatric Nephrology, Dialysis and Transplant Unit, Fondazione IRCCS Ca' Granda - Ospedale Maggiore Policlinico, Milan, Italy.
William MorelloPediatric Nephrology, Dialysis and Transplant Unit, Fondazione IRCCS Ca' Granda - Ospedale Maggiore Policlinico, Milan, Italy.
Lukasz ObryckiDivision of Nephrology, Kidney Transplantation and Hypertension, The Children's Memorial Health Institute, Warsaw, Poland.
Beyhan OmerDepartment of Biochemistry, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey.
Huseyin Adil OnerDivision of Pediatric Nephrology, Istanbul Faculty of Medicine, Istanbul University, Fatih, Istanbul, Turkey.
Ebru Misirli OzdemirDepartment of Pediatrics, Okmeydani Training and Research Hospital, Istanbul, Turkey.
Nese OzkayinDivision of Pediatric Nephrology, Faculty of Medicine, Trakya University, Edirne, Turkey.
Dusan ParipovicDivision of Pediatric Nephrology, University Children's Hospital, Belgrade, Serbia.
Cemile PehlivanogluDivision of Pediatric Nephrology, Umraniye Training and Research Hospital, Istanbul, Turkey.
Seha SaygiliDivision of Pediatric Nephrology, Cerrahpasa Faculty of Medicine, Istanbul University-Cerrahpasa, Istanbul, Turkey.
Franz SchaeferDivision of Pediatric Nephrology, Center for Pediatrics and Adolescent Medicine, Heidelberg University, Heidelberg, Germany.
Susanne SchaeferDivision of Pediatric Nephrology, Center for Pediatrics and Adolescent Medicine, Heidelberg University, Heidelberg, Germany.
Ferah SonmezDivision of Pediatric Nephrology, Faculty of Medicine, Adnan Menderes University, Aydin, Turkey.
Yilmaz TabelDivision of Pediatric Nephrology, Faculty of Medicine, Inonu University, Malatya, Turkey.
Nesrin TasDivision of Pediatric Nephrology, Hacettepe University Faculty of Medicine, Ankara, Turkey.
Mehmet TasdemirDivision of Pediatric Nephrology, Department of Pediatrics, School of Medicine, Koc University, Istanbul, Turkey.
Ana TeixeiraDivision of Pediatric Nephrology, Centro Materno Infantil do Norte, Centro Hospitalar Universitário do Porto, Porto, Portugal.
Demet TekcanDivision of Pediatric Nephrology, Faculty of Medicine, Ondokuz Mayis University, Samsun, Turkey.
Rezan TopalogluDivision of Pediatric Nephrology, Hacettepe University Faculty of Medicine, Ankara, Turkey.
Sebahat TulparDivision of Pediatric Nephrology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, Istanbul, Turkey.
Ozde Nisa TurkkanDivision of Pediatric Nephrology, Faculty of Medicine, Marmara University, Istanbul, Turkey.
Berfin UysalDivision of Pediatric Nephrology, Dortcelik Children's Hospital, Bursa, Turkey.
Metin UysalolDivision of Pediatric Emergency, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey.
Renata VitkevicClinic of Pediatrics, Institute of Clinical Medicine, Vilnius University, Vilnius, Lithuania.
Sevgi YavuzDivision of Pediatric Nephrology, Department of Pediatrics, Kanuni Sultan Suleyman Research and Training Hospital, University of Health Sciences, Istanbul, Turkey.
Sibel YelDivision of Pediatric Nephrology, Faculty of Medicine, Erciyes University, Kayseri, Turkey.
Tarik YildirimDepartment of Pediatrics, Kanuni Sultan Suleyman Research and Training Hospital, University of Health Sciences, Istanbul, Turkey.
Zeynep Yuruk YildirimDepartment of Pediatrics Basic Sciences, Institute of Child Health, Istanbul University, Istanbul, Turkey.
Nurdan YildizDivision of Pediatric Nephrology, Faculty of Medicine, Marmara University, Istanbul, Turkey.
Selcuk YukselDivision of Pediatric Nephrology, Faculty of Medicine, Pamukkale University, Denizli, Turkey.
Eray YurtsevenDepartment of Biostatistics, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey.
Alev YilmazDepartment of Pediatrics Basic Sciences, Institute of Child Health, Istanbul University, Istanbul, Turkey.
Istanbul University · TRSağlık Bilimleri Üniversitesi · TRMarmara University · TRHacettepe University · TRBakırköy Dr.Sadi Konuk Eğitim ve Araştırma Hastanesi · TRCentro Hospitalar do Porto · PTChildren's Memorial Health Institute · PLDokuz Eylül University · TRErciyes University · TRGazi University · TRHeidelberg University · DEKoç University · TRManisa Celal Bayar University · TROndokuz Mayıs University · TRVilnius University · LTAdnan Menderes University · TRAkdeniz University · TRBahçeşehir University · TRBursa Technical University · TRBursa Uludağ Üni̇versi̇tesi̇ · TR

Funding

European Society for Pediatric Nephrology (ESPN)Istanbul Faculty of Medicine FoundationScientific Research Projects Coordination Unit of Istanbul UniversitySociety for Children’s Kidney Health
6 · The paper itself

Abstract

backgroundOne of the most common bacterial infections in childhood is urinary tract infection (UTI). Toll-like receptors (TLRs) contribute to immune response against UTI recognizing specific pathogenic agents. Our aim was to determine whether soluble TLR4 (sTLR4), soluble TLR5 (sTLR5) and interleukin 8 (IL-8) can be used as biomarkers to diagnose UTI. We also aimed to reveal the relationship between urine Heat Shock Protein 70 (uHSP70) and those biomarkers investigated in this study.

methodsA total of 802 children from 37 centers participated in the study. The participants (n = 282) who did not meet the inclusion criteria were excluded from the study. The remaining 520 children, including 191 patients with UTI, 178 patients with non-UTI infections, 50 children with contaminated urine samples, 26 participants with asymptomatic bacteriuria and 75 healthy controls were included in the study. Urine and serum levels of sTLR4, sTLR5 and IL-8 were measured at presentation in all patients and after antibiotic treatment in patients with UTI.

resultsUrine sTLR4 was higher in the UTI group than in the other groups. UTI may be predicted using 1.28 ng/mL as cut-off for urine sTLR4 with 68% sensitivity and 65% specificity (AUC = 0.682). In the UTI group, urine sTLR4 levels were significantly higher in pyelonephritis than in cystitis (p < 0.0001). Post-treatment urine sTLR4 levels in the UTI group were significantly lower than pre-treatment values (p < 0.0001).

conclusionsUrine sTLR4 may be used as a useful biomarker in predicting UTI and subsequent pyelonephritis in children with UTI. A higher resolution version of the Graphical abstract is available as Supplementary information.

Indexed as

PyelonephritisUrinary Tract InfectionsBiomarkersChildHumansInterleukin-8Toll-Like Receptor 4BiomarkersInterleukin-8TLR4 protein, humanToll-Like Receptor 4TLR4Toll-like receptor 4Urinary tract infectionUTIUTILISE study

Identifiers

PMID37462743
OpenAlexW4384626581

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.