Evidence map›Paper›PMID 37462535›Full record

ArticleThe FEBS journal2023

The role of sympathetic innervation in neonatal muscle growth and neuromuscular contractures.

Mason T Runkel, Albaraa Tarabishi, Kritton Shay-Winkler, Marianne E Emmert, Qingnian Goh, Roger Cornwall

Open access · hybridAbstract read
In one paragraph

Article in The FEBS journal, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.0field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Sexual dimorphisms in skeletal muscle: current concepts and research horizons.Journal of applied physiology (Bethesda, Md. : 1985) · 2024
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Mason T RunkelDepartment of Health Sciences, Butler University, Indianapolis, IN, USA.
Albaraa TarabishiDepartment of Biochemistry, University of Cincinnati, OH, USA.
Kritton Shay-WinklerDivision of Orthopaedic Surgery, Cincinnati Children's Hospital Medical Center, OH, USA.
Marianne E EmmertDivision of Orthopaedic Surgery, Cincinnati Children's Hospital Medical Center, OH, USA.
Qingnian GohDivision of Orthopaedic Surgery, Cincinnati Children's Hospital Medical Center, OH, USA.ORCID 0000-0003-4108-2957
Roger CornwallDivision of Orthopaedic Surgery, Cincinnati Children's Hospital Medical Center, OH, USA.ORCID 0000-0003-2205-2883
Cincinnati Children's Hospital Medical Center · USButler University · USUniversity of Cincinnati · US

Funding

Deciphering the pathophysiology of childhood neuromuscular contracturesR01HD098280 · NICHD · CINCINNATI CHILDRENS HOSP MED CTR · PI CORNWALL, ROGER · 2019 to 2023
$2.0M
NICHD NIH HHS R01 HD098280
6 · The paper itself

Abstract

Neonatal brachial plexus injury (NBPI), a leading cause of pediatric upper limb paralysis, results in disabling and incurable muscle contractures that are driven by impaired longitudinal growth of denervated muscles. A rare form of NBPI, which maintains both afferent and sympathetic muscle innervation despite motor denervation, protects against contractures. We have previously ruled out a role for NRG/ErbB signaling, the predominant pathway governing antegrade afferent neuromuscular transmission, in modulating the formation of contractures. Our current study therefore investigated the contributions of sympathetic innervation of skeletal muscle in modulating NBPI-induced contractures. Through chemical sympathectomy and pharmacologic modification with a β

Indexed as

Brachial PlexusContractureMuscular DiseasesAdrenergic AgentsAnimalsChildFemaleHumansMaleMiceMuscle, SkeletalAdrenergic Agentsbeta-adrenergic signalingmuscle growthneonatal brachial plexus injuryneuromuscular contracturessympathetic innervation

Identifiers

PMID37462535
PMCPMC10592371
OpenAlexW4384627366

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.