Evidence map›Paper›PMID 37462530›Full record

ArticleJournal of medicinal chemistry2023

Discovery of Novel Oleamide Analogues as Brain-Penetrant Positive Allosteric Serotonin 5-HT

Jianping Chen, Erik J Garcia, Christina R Merritt, Joshua C Zamora, Andrew A Bolinger, Konrad Pazdrak, Susan J Stafford, Randy C Mifflin, Eric A Wold, Christopher T Wild and 4 more

Open access · greenAbstract read
In one paragraph

Article in Journal of medicinal chemistry, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
2.1field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 14 citations in OpenAlex.

  1. Review
  2. GPCR Heterodimers: Implications for Biased Signaling.Handbook of experimental pharmacology · 2026
    Review
  3. The Effect of Serotonin 5-HTAddiction biology · 2025
    Article
  4. Article
  5. Article
  6. Targeting the 5-HTJournal of medicinal chemistry · 2025
    Article
  7. Review
  8. Article
  9. Article
  10. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 1 institution in 1 country.

Jianping ChenCenter for Addiction Sciences and Therapeutics, University of Texas Medical Branch (UTMB), Galveston, Texas 77555, United States.
Erik J GarciaCenter for Addiction Sciences and Therapeutics, University of Texas Medical Branch (UTMB), Galveston, Texas 77555, United States.ORCID 0000-0003-4760-7048
Christina R MerrittCenter for Addiction Sciences and Therapeutics, University of Texas Medical Branch (UTMB), Galveston, Texas 77555, United States.
Joshua C ZamoraCenter for Addiction Sciences and Therapeutics, University of Texas Medical Branch (UTMB), Galveston, Texas 77555, United States.
Andrew A BolingerCenter for Addiction Sciences and Therapeutics, University of Texas Medical Branch (UTMB), Galveston, Texas 77555, United States.
Konrad PazdrakCenter for Addiction Sciences and Therapeutics, University of Texas Medical Branch (UTMB), Galveston, Texas 77555, United States.
Susan J StaffordCenter for Addiction Sciences and Therapeutics, University of Texas Medical Branch (UTMB), Galveston, Texas 77555, United States.
Randy C MifflinCenter for Addiction Sciences and Therapeutics, University of Texas Medical Branch (UTMB), Galveston, Texas 77555, United States.
Eric A WoldCenter for Addiction Sciences and Therapeutics, University of Texas Medical Branch (UTMB), Galveston, Texas 77555, United States.
Christopher T WildCenter for Addiction Sciences and Therapeutics, University of Texas Medical Branch (UTMB), Galveston, Texas 77555, United States.
Haiying ChenCenter for Addiction Sciences and Therapeutics, University of Texas Medical Branch (UTMB), Galveston, Texas 77555, United States.
Noelle C AnastasioCenter for Addiction Sciences and Therapeutics, University of Texas Medical Branch (UTMB), Galveston, Texas 77555, United States.ORCID 0000-0001-5579-4213
Kathryn A CunninghamCenter for Addiction Sciences and Therapeutics, University of Texas Medical Branch (UTMB), Galveston, Texas 77555, United States.ORCID 0000-0002-4257-1739
Jia ZhouCenter for Addiction Sciences and Therapeutics, University of Texas Medical Branch (UTMB), Galveston, Texas 77555, United States.ORCID 0000-0002-2811-1090
The University of Texas Medical Branch at Galveston · US

Funding

5-HT2 Receptor Allosterism in Cocaine Use DisorderR01DA038446 · NIDA · UNIVERSITY OF TEXAS MED BR GALVESTON · PI Kathryn A. Cunningham, Jia Zhou · 2015 to 2026
$5.3M
Translational Explorations in Substance Use DisordersT32DA007287 · NIDA · UNIVERSITY OF TEXAS MEDICAL BR GALVESTON · PI Kathryn A. Cunningham, Jonathan Dean Hommel · 1994 to 2026
$4.7M
Core Center for Translational Addiction SciencesP30DA028821 · NIDA · UNIVERSITY OF TEXAS MED BR GALVESTON · PI CUNNINGHAM, KATHRYN A. · 2009 to 2010
$1.5M
Addiction and the Neuropharmacology of PsychostimulantsK05DA020087 · NIDA · UNIVERSITY OF TEXAS MEDICAL BR GALVESTON · PI CUNNINGHAM, KATHRYN A. · 2005 to 2015
$1.3M
Optimization of Allosteric Modulators of 5-HT2C ReceptorR21MH093844 · NIMH · UNIVERSITY OF TEXAS MED BR GALVESTON · PI CUNNINGHAM, KATHRYN A., ZHOU, JIA · 2012 to 2013
$450k
5-HT2C Receptor PAMs as Neurotherapeutics for Cocaine Use DisorderF31DA045511 · NIDA · UNIVERSITY OF TEXAS MED BR GALVESTON · PI WOLD, ERIC A. · 2018 to 2020
$99k
Developing 5-HT2C Receptor Allosteric Modulators to Treat Cocaine Use DisorderF31DA038922 · NIDA · UNIVERSITY OF TEXAS MED BR GALVESTON · PI WILD, CHRISTOPHER TIMOTHY · 2016 to 2017
$63k
NIDA NIH HHS F31 DA038922NIDA NIH HHS F31 DA045511NIDA NIH HHS K05 DA020087NIDA NIH HHS P30 DA028821NIDA NIH HHS R01 DA038446NIDA NIH HHS T32 DA007287NIMH NIH HHS HHSN271201300017CNIMH NIH HHS R21 MH093844
6 · The paper itself

Abstract

The serotonin 5-HT

Indexed as

Receptor, Serotonin, 5-HT2ASerotoninBrainOleic AcidsReceptor, Serotonin, 5-HT2COleic AcidsoleylamideReceptor, Serotonin, 5-HT2AReceptor, Serotonin, 5-HT2CSerotonin

Identifiers

PMID37462530
PMCPMC10853020
OpenAlexW4384626996

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.