ArticleThe Plant cell2023
The osmotic stress-activated receptor-like kinase DPY1 mediates SnRK2 kinase activation and drought tolerance in Setaria.
Article in The Plant cell, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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16 citing papers in PubMed, 30 citations in OpenAlex.
- Integrative transcriptional regulatory networks governing cereal root responses to heavy metals and drought.Plant cell reports · 2026Review
- Signaling mechanisms governing the environmental modulation of fruit quality development.Horticulture research · 2026Article
- The miR164b-SiNAC015 Module Regulates Drought Tolerance by Scavenging Reactive Oxygen Species in Foxtail Millet.Plant biotechnology journal · 2026Article
- A mini-review on the role of leucine-rich repeat receptor-like kinases (LRR-RLKs) in plant responses to drought stress.Molecular biology reports · 2025Review
- The Arabidopsis PM19L1 Protein Functions as a Regulator of Germination Under Osmotic Stress.Plant direct · 2025Article
- Mechanisms of Salt and Drought Stress Responses in Foxtail Millet.Plants (Basel, Switzerland) · 2025Review
- Comprehensive co-expression network reveals the fine-tuning of AsHSFA2c in balancing drought tolerance and growth in oat.Communications biology · 2025Article
- Genome-wide characterization and expression profiling of theFrontiers in plant science · 2025Article
- Physiological and molecular mechanisms of drought adaptation in foxtail millet: insights and future perspectives.Frontiers in plant science · 2025Review
- Effects of post-harvest ' rubbing-sweating ' drying treatment on the accumulation of bioactive compounds inFrontiers in plant science · 2025Article
- Osmotic signaling releases PP2C-mediated inhibition of Arabidopsis SnRK2s via the receptor-like cytoplasmic kinase BIK1.The EMBO journal · 2024Article
- Comprehensive Morphological and Molecular Insights into Drought Tolerance Variation at Germination Stage inPlants (Basel, Switzerland) · 2024Article
- Transcriptome and Metabolome Analyses Reveal the Molecular Mechanisms ofPlants (Basel, Switzerland) · 2024Article
- SlCPK27 cross-links SlHY5 and SlPIF4 in brassinosteroid-dependent photo- and thermo-morphogenesis in tomato.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- DNA Methylation Dynamics in Response to Drought Stress in Crops.Plants (Basel, Switzerland) · 2024Review
- Identification and Characterization of thePlants (Basel, Switzerland) · 2024Article
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Authors and funding
20 authors at 4 institutions in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
Plant genomes encode many receptor-like kinases (RLKs) that localize to the cell surface and perceive a wide variety of environmental cues to initiate downstream signaling cascades. Whether these RLKs participate in dehydration stress signaling in plants is largely unknown. DROOPY LEAF1 (DPY1), a leucine-rich repeat (LRR)-RLK, was recently shown to regulate plant architecture by orchestrating early brassinosteroid signaling in foxtail millet (Setaria italica). Here, we show that DPY1 is essential for the acclimation of foxtail millet to drought stress. DPY1 can be phosphorylated and activated in response to osmotic stress and is required for more than half of osmotic stress-induced global phosphorylation events, including the phosphorylation of sucrose nonfermenting kinase 2s (SnRK2s), the central kinases involved in osmotic stress. DPY1 acts upstream of STRESS-ACTIVATED PROTEIN KINASE 6 (SAPK6, a subclass I SnRK2) and is required for full SAPK6 activation, thereby allowing regulation of downstream genes to mount a response against drought stress. These signaling events are largely independent of DPY1-mediated brassinosteroid signaling. The DPY1-SAPK6 module is specific to seed plants and is absent in ancestral nonseed plants. Our findings reveal a dehydration stress-activated RLK that plays an indispensable role in osmotic stress signaling and mediates SnRK2 activation at the cell surface.
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