Evidence map›Paper›PMID 37462219›Full record

ArticleJournal of chemical information and modeling2023

Understanding Drug Skin Permeation Enhancers Using Molecular Dynamics Simulations.

Christian Wennberg, Magnus Lundborg, Erik Lindahl, Lars Norlén

Open access · hybridAbstract read
In one paragraph

Article in Journal of chemical information and modeling, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 1 pooled it
2.1field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 1 synthesis or guideline pooled it, 19 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Article
  6. Review
  7. Article
  8. Article
  9. Article
  10. Simulating the Skin Permeation Process of Ionizable Molecules.Journal of chemical information and modeling · 2024
    Article
  11. Molecular Organization of the Skin Barrier.Acta dermato-venereologica · 2023
    Review
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 1 country.

Christian WennbergScience for Life Laboratory, ERCO Pharma AB, 171 65 Solna, Sweden.ORCID 0000-0003-4012-1678
Magnus LundborgScience for Life Laboratory, ERCO Pharma AB, 171 65 Solna, Sweden.ORCID 0000-0002-0873-7854
Erik LindahlDepartment of Biophysics and Biochemistry, Stockholm University, 106 91 Stockholm, Sweden.
Lars NorlénDepartment of Cell and Molecular Biology (CMB), Karolinska Institutet, 171 77 Solna, Sweden.ORCID 0000-0002-8049-2556
Science for Life Laboratory · SEKarolinska University Hospital · SEStockholm University · SE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Our skin constitutes an effective permeability barrier that protects the body from exogenous substances but concomitantly severely limits the number of pharmaceutical drugs that can be delivered transdermally. In topical formulation design, chemical permeation enhancers (PEs) are used to increase drug skin permeability.

Indexed as

Molecular Dynamics SimulationSkin AbsorptionCaffeineMetronidazoleNaproxenPermeabilitySkinWaterCaffeineMetronidazoleNaproxenWater

Identifiers

PMID37462219
PMCPMC10428223
OpenAlexW4384626629

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.