Evidence map›Paper›PMID 37461721›Full record

ArticlebioRxiv : the preprint server for biology2023

Intratumoral immune triads are required for adoptive T cell therapy-mediated elimination of solid tumors.

Gabriel Espinosa-Carrasco, Aurora Scrivo, Paul Zumbo, Asim Dave, Doron Betel, Matthew Hellmann, Bryan M Burt, Hyun-Sung Lee, Andrea Schietinger

Open access · greenAbstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 5 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 1 country.

Gabriel Espinosa-CarrascoImmunology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Aurora ScrivoDepartment of Developmental and Molecular Biology, and Institute for Aging Studies, Albert Einstein College of Medicine, Bronx, NY, USA.
Paul ZumboDepartment of Physiology and Biophysics, Weill Cornell Medicine, New York, NY, USA.
Asim DaveImmunology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Doron BetelInstitute for Computational Biomedicine, Weill Cornell Medicine, New York, NY, USA.
Matthew HellmannOncology Service, Memorial Sloan Kettering Cancer Center, New York, NY; Weill Cornell Medical College, Cornell University, New York, NY, USA.
Bryan M BurtSystems Onco-Immunology Laboratory, David J. Sugarbaker Division of Thoracic Surgery, Michael E. DeBakey Department of Surgery, Baylor College of Medicine, Houston, TX.
Hyun-Sung LeeSystems Onco-Immunology Laboratory, David J. Sugarbaker Division of Thoracic Surgery, Michael E. DeBakey Department of Surgery, Baylor College of Medicine, Houston, TX.
Andrea SchietingerImmunology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Memorial Sloan Kettering Cancer Center · USBaylor College of Medicine · USCornell University · USAlbert Einstein College of Medicine · US

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Nicholas D Socci · 1985 to 2026
$347.4M
Proteomic determinants of response to checkpoint blockade in malignant pleuralmesotheliomaR37CA248478 · NCI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Bryan Michael Burt · 2021 to 2026
$2.9M
Spatiotemporal regulation of T cell fate decisions in cancerDP2CA225212 · NCI · SLOAN-KETTERING INST CAN RESEARCH · PI SCHIETINGER, ANDREA · 2017 to 2017
$2.6M
TOX-driven CD8 T cell differentiation and dysfunction in tumorsR01CA269733 · NCI · SLOAN-KETTERING INST CAN RESEARCH · PI Andrea Schietinger · 2023 to 2026
$2.4M
NCI NIH HHS DP2 CA225212NCI NIH HHS P30 CA008748NCI NIH HHS R01 CA269733NCI NIH HHS R37 CA248478
6 · The paper itself

Abstract

Tumor-reactive CD8 T cells found in cancer patients are frequently dysfunctional, unable to halt tumor growth. Adoptive T cell transfer (ACT), the administration of large numbers of

Identifiers

PMID37461721
PMCPMC10349998
OpenAlexW4383105909

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.