Evidence map›Paper›PMID 37461714›Full record

ArticleResearch square2023

Structural alterations in the amygdala and impaired social incentive learning in a mouse model of a genetic variant associated with neurodevelopmental disorders.

Takeshi Hiramoto, Akira Sumiyoshi, Risa Kato, Takahira Yamauchi, Gina Kang, Bailey Matsumura, Lucas J Stevens, Rie Ryoke, Hiroi Nonaka, Akihiro Machida and 5 more

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in Research square, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 3 institutions in 3 countries.

Takeshi HiramotoDepartment of Pharmacology, UT Health San Antonio, Texas 78229, USA.
Akira SumiyoshiInstitute of Development, Aging and Cancer, Tohoku University, 4-1 Seiryo-cho, Aoba-ku, Sendai 980-8575, Japan.
Risa KatoLaboratory of Human-Animal Interaction and Reciprocity, Azabu University, 1-17-71 Fuchinobe, Chuo-ku, Sagamihara, Kanagawa 252-5201, Japan.
Takahira YamauchiDepartment of Pharmacology, UT Health San Antonio, Texas 78229, USA.
Gina KangDepartment of Pharmacology, UT Health San Antonio, Texas 78229, USA.
Bailey MatsumuraDepartment of Pharmacology, UT Health San Antonio, Texas 78229, USA.
Lucas J StevensDepartment of Pharmacology, UT Health San Antonio, Texas 78229, USA.
Rie RyokeInstitute of Development, Aging and Cancer, Tohoku University, 4-1 Seiryo-cho, Aoba-ku, Sendai 980-8575, Japan.
Hiroi NonakaInstitute of Development, Aging and Cancer, Tohoku University, 4-1 Seiryo-cho, Aoba-ku, Sendai 980-8575, Japan.
Akihiro MachidaLaboratory of Human-Animal Interaction and Reciprocity, Azabu University, 1-17-71 Fuchinobe, Chuo-ku, Sagamihara, Kanagawa 252-5201, Japan.
Kensaku NomotoLaboratory of Human-Animal Interaction and Reciprocity, Azabu University, 1-17-71 Fuchinobe, Chuo-ku, Sagamihara, Kanagawa 252-5201, Japan.
Kazutaka MogiLaboratory of Human-Animal Interaction and Reciprocity, Azabu University, 1-17-71 Fuchinobe, Chuo-ku, Sagamihara, Kanagawa 252-5201, Japan.
Takefumi KikusuiLaboratory of Human-Animal Interaction and Reciprocity, Azabu University, 1-17-71 Fuchinobe, Chuo-ku, Sagamihara, Kanagawa 252-5201, Japan.ORCID 0000-0002-3134-5859
Ryuta KawashimaInstitute of Development, Aging and Cancer, Tohoku University, 4-1 Seiryo-cho, Aoba-ku, Sendai 980-8575, Japan.
Noboru HiroiDepartment of Pharmacology, UT Health San Antonio, Texas 78229, USA.ORCID 0000-0002-6846-5969
The University of Texas Health Science Center at San Antonio · USAzabu University · JPTohoku University · JP

Funding

Postnatal mechanisms of cognitive development in miceR01MH099660 · NIMH · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI Noboru Hiroi · 2013 to 2026
$5.9M
Structure and Function of Neonatal Social Communication in Genetic Mouse Models of AutismR01DC015776 · NIDCD · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI HIROI, NOBORU · 2017 to 2021
$1.7M
22q11 Genes and Complex Behavior in MiceR21HD053114 · NICHD · ALBERT EINSTEIN COLLEGE OF MEDICINE · PI HIROI, NOBORU · 2008 to 2009
$453k
Molecular and Cellular Mechanisms of Chromosome 18q23 DysmyelinationR03HD108551 · NICHD · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI CODY, JANNINE DE MARS, HIROI, NOBORU · 2023 to 2024
$233k
NICHD NIH HHS R03 HD108551NICHD NIH HHS R21 HD053114NIDCD NIH HHS R01 DC015776NIMH NIH HHS R01 MH099660
6 · The paper itself

Abstract

Copy number variants (CNVs) are robustly associated with psychiatric disorders and their dimensions and changes in brain structures and behavior. However, as CNVs contain many genes, the precise gene-phenotype relationship remains unclear. Although various volumetric alterations in the brains of 22q11.2 CNV carriers have been identified in humans and mouse models, it is unknown how the genes in the 22q11.2 region individually contribute to structural alterations and associated mental illnesses and their dimensions. Our previous studies have identified

Indexed as

22q11.222q11.2 CNVamygdalaautismCNVschizophreniasocial incentive motivationTbx1volumetric MRI

Identifiers

PMID37461714
PMCPMC10350205
OpenAlexW4382653936

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.