Evidence map›Paper›PMID 37461650›Full record

ArticlemedRxiv : the preprint server for health sciences2023

Structure-based network analysis predicts mutations associated with inherited retinal disease.

Blake M Hauser, Yuyang Luo, Anusha Nathan, Gaurav D Gaiha, Demetrios Vavvas, Jason Comander, Eric A Pierce, Emily M Place, Kinga M Bujakowska, Elizabeth J Rossin

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in medRxiv : the preprint server for health sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Blake M HauserHarvard Medical School, Boston, MA.
Yuyang LuoDepartment of Ophthalmology, Massachusetts Eye and Ear, Harvard Medical School, Boston, MA.
Anusha NathanRagon Institute of Mass General, MIT, and Harvard, Cambridge, MA.
Gaurav D GaihaRagon Institute of Mass General, MIT, and Harvard, Cambridge, MA.
Demetrios VavvasDepartment of Ophthalmology, Massachusetts Eye and Ear, Harvard Medical School, Boston, MA.
Jason ComanderDepartment of Ophthalmology, Massachusetts Eye and Ear, Harvard Medical School, Boston, MA.
Eric A PierceDepartment of Ophthalmology, Massachusetts Eye and Ear, Harvard Medical School, Boston, MA.
Emily M PlaceDepartment of Ophthalmology, Massachusetts Eye and Ear, Harvard Medical School, Boston, MA.
Kinga M BujakowskaDepartment of Ophthalmology, Massachusetts Eye and Ear, Harvard Medical School, Boston, MA.
Elizabeth J RossinDepartment of Ophthalmology, Massachusetts Eye and Ear, Harvard Medical School, Boston, MA.
Massachusetts Eye and Ear Infirmary · USRagon Institute of MGH, MIT and Harvard · USHarvard University · US

Funding

Precision Medicine for Inherited Retinal DegenerationsR01EY012910 · NEI · UNIVERSITY OF PENNSYLVANIA · PI Eric A Pierce · 1999 to 2026
$15.9M
P30 Core Grant for Vision ResearchP30EY014104 · NEI · MASSACHUSETTS EYE AND EAR INFIRMARY · PI Janey L Wiggs · 2002 to 2026
$15.1M
Medical Scientist Training ProgramT32GM144273 · NIGMS · HARVARD MEDICAL SCHOOL · PI David Shumway Jones, Jacqueline A. Lees · 2022 to 2026
$14.7M
Mass Eye and Ear-Vision Clinical Scientist Development ProgramK12EY016335 · NEI · MASSACHUSETTS EYE AND EAR INFIRMARY · PI Reza Dana · 2004 to 2026
$12.3M
Improving the throughput of diagnosis and treatment of inherited diseases of the retinaR01EY031036 · NEI · MASSACHUSETTS EYE AND EAR INFIRMARY · PI COMANDER, JASON · 2020 to 2024
$2.1M
Epitope focusing using structure-based immunogen design approachesF30AI160908 · NIAID · HARVARD MEDICAL SCHOOL · PI HAUSER, BLAKE MARIE · 2021 to 2023
$91k
NEI NIH HHS K12 EY016335NEI NIH HHS P30 EY014104NEI NIH HHS R01 EY012910NEI NIH HHS R01 EY031036NIAID NIH HHS F30 AI160908NIGMS NIH HHS T32 GM144273
6 · The paper itself

Abstract

With continued advances in gene sequencing technologies comes the need to develop better tools to understand which mutations cause disease. Here we validate structure-based network analysis (SBNA)

Identifiers

PMID37461650
PMCPMC10350150
OpenAlexW4383311603

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.