Evidence map›Paper›PMID 37461642›Full record

ArticlebioRxiv : the preprint server for biology2023

The Cellular Underpinnings of the Human Cortical Connectome.

Xi-Han Zhang, Kevin M Anderson, Hao-Ming Dong, Sidhant Chopra, Elvisha Dhamala, Prashant S Emani, Daniel Margulies, Avram J Holmes

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 7 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 2 countries.

Xi-Han ZhangDepartment of Psychology, Yale University, New Haven, CT, USA.
Kevin M AndersonDepartment of Psychology, Yale University, New Haven, CT, USA.
Hao-Ming DongDepartment of Psychology, Yale University, New Haven, CT, USA.
Sidhant ChopraDepartment of Psychology, Yale University, New Haven, CT, USA.
Elvisha DhamalaDepartment of Psychology, Yale University, New Haven, CT, USA.
Prashant S EmaniProgram in Computational Biology and Bioinformatics, Yale University, New Haven, CT, USA.
Daniel MarguliesCNRS, Integrative Neuroscience and Cognition Center (UMR 8002), Université de Paris, Paris, France.
Avram J HolmesDepartment of Psychology, Yale University, New Haven, CT, USA.
Yale University · USCentre National de la Recherche Scientifique · FRNorthwell Health · USRutgers, The State University of New Jersey · US

Funding

Mapping the Human Connectome: Structure, Function, and HeritabilityU54MH091657 · NIMH · WASHINGTON UNIVERSITY · PI UGURBIL, KAMIL, VAN ESSEN, DAVID C · 2010 to 2014
$34.7M
Functional genomics of the human connectome in psychiatric illnessR01MH120080 · NIMH · YALE UNIVERSITY · PI AVRAM J HOLMES, Thomas Boon Thye Yeo · 2019 to 2026
$4.8M
Integrative analysis of genomics and imaging data from the BRAIN Initiative and other public data sourcesRF1MH123245 · NIMH · YALE UNIVERSITY · PI GERSTEIN, MARK BENDER, HOLMES, AVRAM J · 2021 to 2021
$1.3M
NIMH NIH HHS R01 MH120080NIMH NIH HHS RF1 MH123245NIMH NIH HHS U54 MH091657
6 · The paper itself

Abstract

The functional properties of the human brain arise, in part, from the vast assortment of cell types that pattern the cortex. The cortical sheet can be broadly divided into distinct networks, which are further embedded into processing streams, or gradients, that extend from unimodal systems through higher-order association territories. Here, using transcriptional data from the Allen Human Brain Atlas, we demonstrate that imputed cell type distributions are spatially coupled to the functional organization of cortex, as estimated through fMRI. Cortical cellular profiles follow the macro-scale organization of the functional gradients as well as the associated large-scale networks. Distinct cellular fingerprints were evident across networks, and a classifier trained on post-mortem cell-type distributions was able to predict the functional network allegiance of cortical tissue samples. These data indicate that the

Indexed as

Cell-type imputationCortical organizationexcitatory neuronsfMRIFunctional gradientsFunctional networksgene transcriptionInhibitory interneurons

Identifiers

PMID37461642
PMCPMC10349999
OpenAlexW4383371137

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.