Evidence map›Paper›PMID 37461622›Full record

ArticlebioRxiv : the preprint server for biology2023

Unconventional Activation of IRE1 Enhances TH17 Responses and Promotes Neutrophilic Airway Inflammation.

Dandan Wu, Xing Zhang, Kourtney M Zimmerly, Ruoning Wang, Amanda Livingston, Takao Iwawaki, Ashok Kumar, Xiang Wu, Michael A Mandell, Meilian Liu and 1 more

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 3 countries.

Dandan WuDepartment of Molecular Genetics and Microbiology, University of New Mexico School of Medicine, Albuquerque, NM 87131, USA.
Xing ZhangDepartment of Biochemistry and Molecular Biology, University of New Mexico School of Medicine, Albuquerque, NM 87131, USA.
Kourtney M ZimmerlyDepartment of Molecular Genetics and Microbiology, University of New Mexico School of Medicine, Albuquerque, NM 87131, USA.
Ruoning WangDepartment of Molecular Genetics and Microbiology, University of New Mexico School of Medicine, Albuquerque, NM 87131, USA.
Amanda LivingstonDepartment of Molecular Genetics and Microbiology, University of New Mexico School of Medicine, Albuquerque, NM 87131, USA.
Takao IwawakiDivision of Cell Medicine, Medical Research Institute, Kanazawa Medical University, Ishikawa 920-0293, Japan.
Ashok KumarDepartment of Pharmacological and Pharmaceutical Sciences, University of Houston College of Pharmacy, Houston, TX 77204, USA.
Xiang WuDepartment of Molecular Genetics and Microbiology, University of New Mexico School of Medicine, Albuquerque, NM 87131, USA.
Michael A MandellDepartment of Molecular Genetics and Microbiology, University of New Mexico School of Medicine, Albuquerque, NM 87131, USA.
Meilian LiuDepartment of Biochemistry and Molecular Biology, University of New Mexico School of Medicine, Albuquerque, NM 87131, USA.
Xuexian O YangDepartment of Molecular Genetics and Microbiology, University of New Mexico School of Medicine, Albuquerque, NM 87131, USA.
University of New Mexico · USCentral South University · CNKanazawa Medical University · JPUniversity of Houston · US

Funding

WOMEN'S CANCERS RESEARCH PROGRAMP30CA118100 · NCI · UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR · PI Yolanda Sanchez · 2005 to 2026
$57.1M
UNM TRAININGP50GM085273 · NIGMS · UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR · PI WANDINGER-NESS, ANGELA · 2009 to 2018
$26.1M
Unfolded Protein Response and Autophagy in T Helper Cell Effector FunctionP20GM121176 · NIGMS · UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR · PI Samuel Joseph Endicott · 2017 to 2026
$24.9M
The Role of Adiponectin in Regulating Group 2 Innate Lymphoid Cells and Browning in FatR01DK110439 · NIDDK · UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR · PI LIU, MEILIAN · 2017 to 2021
$1.8M
The Cytokine Suppressor CIS in Giant Cell PneumonitisR01HL148337 · NHLBI · UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR · PI YANG, XUEXIAN · 2020 to 2023
$1.5M
Leptin Promotes Allergic Asthma through Unfolded Protein ResponsesR21AI142200 · NIAID · UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR · PI YANG, XUEXIAN · 2019 to 2020
$417k
Control of allergic airway inflammationR56AI116772 · NIAID · UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR · PI YANG, XUEXIAN · 2016 to 2016
$366k
NCI NIH HHS P30 CA118100NHLBI NIH HHS R01 HL148337NIAID NIH HHS R21 AI142200NIAID NIH HHS R56 AI116772NIDDK NIH HHS R01 DK110439NIGMS NIH HHS P20 GM121176NIGMS NIH HHS P50 GM085273
6 · The paper itself

Abstract

Treatment-refractory severe asthma manifests a neutrophilic phenotype associated with TH17 responses. Heightened unfolded protein responses (UPRs) are associated with the risk of asthma, including severe asthma. However, how UPRs participate in the deregulation of TH17 cells leading to this type of asthma remains elusive. In this study, we investigated the role of the UPR sensor IRE1 in TH17 cell function and neutrophilic airway inflammation. We found that IRE1 is induced in fungal asthma and is highly expressed in TH17 cells relative to naïve CD4

Indexed as

IRE1JAK2neutrophilic asthmaTH17 cellUPR

Identifiers

PMID37461622
PMCPMC10349957
OpenAlexW4382931068

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.