Evidence map›Paper›PMID 37461616›Full record

ArticlebioRxiv : the preprint server for biology2024

Interpreting

Shushan Toneyan, Peter K Koo

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors.

Shushan ToneyanSimons Center for Quantitative Biology, Cold Spring Harbor Laboratory, NY, USA.ORCID 0000-0002-1365-3241
Peter K KooSimons Center for Quantitative Biology, Cold Spring Harbor Laboratory, NY, USA.ORCID 0000-0001-8722-0038

Funding

Interpretable Computational Models of Functional Genomics DataR01HG012131 · NHGRI · COLD SPRING HARBOR LABORATORY · PI Peter K Koo · 2022 to 2026
$2.1M
Reliable post hoc interpretations of deep learning in genomicsR01GM149921 · NIGMS · COLD SPRING HARBOR LABORATORY · PI Peter K Koo · 2023 to 2026
$1.7M
Graphical Processing Units and a Large-Memory Compute Node for Applications in Genomics, Neuroscience, and Structural BiologyS10OD028632 · OD · COLD SPRING HARBOR LABORATORY · PI SIEPEL, ADAM CHARLES · 2020 to 2020
$437k
NHGRI NIH HHS R01 HG012131NIGMS NIH HHS R01 GM149921NIH HHS S10 OD028632
6 · The paper itself

Abstract

The rise of large-scale, sequence-based deep neural networks (DNNs) for predicting gene expression has introduced challenges in their evaluation and interpretation. Current evaluations align DNN predictions with experimental perturbation assays, which provides insights into the generalization capabilities within the studied loci but offers a limited perspective of what drives their predictions. Moreover, existing model explainability tools focus mainly on motif analysis, which becomes complex when interpreting longer sequences. Here we introduce CREME, an

Identifiers

PMID37461616
PMCPMC10349992

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.