Evidence map›Paper›PMID 37461611›Full record

ArticlebioRxiv : the preprint server for biology2023

Aaron Gochman, Tri Q Do, Kyungsoo Kim, Jacob A Schwarz, Madelaine P Thorpe, Daniel J Blackwell, Abigail N Smith, Wendell S Akers, Razvan L Cornea, Derek R Laver and 2 more

Open access · greenAbstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 3 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

  • Updated by
    2024
5 · Who and what money

Authors and funding

12 authors at 5 institutions in 2 countries.

Aaron Gochman
Tri Q Do
Kyungsoo Kim
Jacob A Schwarz
Madelaine P Thorpe
Daniel J Blackwell
Abigail N Smith
Wendell S Akers
Razvan L Cornea
Derek R Laver
Jeffrey N Johnston
Bjorn C KnollmannORCID 0000-0003-4956-9735
Vanderbilt University Medical Center · USVanderbilt University · USUniversity of Minnesota · USHunter Medical Research Institute · AULipscomb University · US

Funding

Development of a Mirror-Image Natural Product as an Antiarrhythmic TherapeuticR01HL151223 · NHLBI · VANDERBILT UNIVERSITY · PI JOHNSTON, JEFFREY NICHOLAS · 2020 to 2023
$3.1M
Deconvolution of Physicochemical Properties Contributing to Passive Diffusion of DepsipeptidesF31HL164064 · NHLBI · VANDERBILT UNIVERSITY · PI THORPE, MADELAINE PAIGE · 2023 to 2024
$53k
NHLBI NIH HHS F31 HL164064NHLBI NIH HHS R01 HL151223
6 · The paper itself

Abstract

Ca Significance statement: The cardiac ryanodine receptor (RyR2) is an untapped target in the stagnant field of antiarrhythmic drug development. We have confirmed RyR2 as an antiarrhythmic target in a mouse model of sudden cardiac death and shown the therapeutic efficacy of a second enantiomeric natural product.

Identifiers

PMID37461611
PMCPMC10349981
OpenAlexW4383106036

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.