ArticleResearch square2023
NDUFS4 Regulates Cristae Remodeling in Diabetic Kidney Disease.
Koki Mise, Jianyin Long, Daniel L Galvan, Zengchun Ye, Guizhen Fan, Irina I Serysheva, Travis I Moore, Jun Wada, Paul T Schumacker, Benny H Chang and 1 more
Open access · greenAbstract readPreprint
In one paragraphArticle in Research square, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
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3 · Its place in the literatureWho cites it
0 citing papers in PubMed, 4 citations in OpenAlex.
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4 · The recordCorrections and comments
5 · Who and what moneyAuthors and funding
11 authors at 5 institutions in 3 countries.
Koki MiseSection of Nephrology, The University of Texas MD Anderson Cancer Center, Houston, Texas.
Jianyin LongSection of Nephrology, The University of Texas MD Anderson Cancer Center, Houston, Texas.
Daniel L GalvanDepartment of Hematopathology, The University of Texas MD Anderson Cancer Center, Houston, Texas.ORCID 0000-0001-7541-6252 Zengchun YeDivision of Nephrology, The Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China.
Guizhen FanDepartment of Biochemistry and Molecular Biology, The University of Texas Health Science Center at Houston, Houston, Texas.
Irina I SeryshevaDepartment of Biochemistry and Molecular Biology, The University of Texas Health Science Center at Houston, Houston, Texas.ORCID 0000-0001-6266-3422 Travis I MooreDepartment of Integrative Biology and Pharmacology, The University of Texas Health Science Center at Houston, Houston, Texas.
Jun WadaDepartment of Nephrology, Rheumatology, Endocrinology & Metabolism, Okayama University Graduate School of Medicine, Dentistry & Pharmaceutical Sciences, Okayama, Japan.ORCID 0000-0003-1468-5170 Paul T SchumackerDepartment of Pediatrics, Feinberg School of Medicine, Northwestern University, Chicago, IL.
Benny H ChangSection of Nephrology, The University of Texas MD Anderson Cancer Center, Houston, Texas.
Farhad R DaneshSection of Nephrology, The University of Texas MD Anderson Cancer Center, Houston, Texas.ORCID 0000-0001-6849-5239 The University of Texas MD Anderson Cancer Center · USThe University of Texas Health Science Center at Houston · USNorthwestern University · USOkayama University · JPSun Yat-sen University · CN
Funding
Tumor Evolution and Metastasis ProgramP30CA016672 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI Fabien Delerue · 1985 to 2026
$290.8MTumor BiologyP30CA125123 · NCI · BAYLOR COLLEGE OF MEDICINE · PI Michael M Ittmann · 2007 to 2026
$73.9MMicroRNA In Diabetic NephropathyR01DK091310 · NIDDK · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI DANESH, FARHAD R · 2011 to 2024
$5.3MRole of Rho Kinases in Diabetic NephropathyR01DK078900 · NIDDK · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI DANESH, FARHAD R · 2009 to 2024
$5.2MStructure-Function Studies Of IP3R ChannelsR01GM072804 · NIGMS · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI SERYSHEVA, IRINA I · 2005 to 2023
$4.8MMechanoregulation of the Leukocyte Specific Integrin LFA-1 by the Actin CytoskeletonK01HL143111 · NHLBI · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI MOORE, TRAVIS I · 2018 to 2022
$856kNCI NIH HHS P30 CA016672NCI NIH HHS P30 CA125123NHLBI NIH HHS K01 HL143111NIDDK NIH HHS R01 DK078900NIDDK NIH HHS R01 DK091310NIGMS NIH HHS R01 GM072804
6 · The paper itselfAbstract
The mitochondrial electron transport chain (ETC) is a highly adaptive process to meet metabolic demands of the cell, and its dysregulation has been associated with diverse clinical pathologies. However, the role and nature of impaired ETC in kidney diseases remains poorly understood. Here, we generated diabetic mice with podocyte-specific overexpression of Ndufs4, an accessory subunit of mitochondrial complex I, as a model to investigate the role of ETC integrity in diabetic kidney disease (DKD). We find that these conditional mice exhibit significant improvements in cristae morphology, mitochondrial dynamics, and albuminuria. By coupling proximity labeling with super-resolution imaging, we also identify the role of cristae shaping proteins in linking NDUFS4 with improved cristae morphology. Taken together, we discover the central role of NDUFS4 as a powerful regulator of cristae remodeling, respiratory supercomplexes assembly, and mitochondrial ultrastructure
Identifiers
PMID37461606
PMCPMC10350115
OpenAlexW4382700072
What OpenQuestion holds
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