ArticlebioRxiv : the preprint server for biology2023
A familial missense variant in the Alzheimer's Disease gene
Elnaz Fazeli, Daniel D Child, Stephanie A Bucks, Miki Stovarsky, Gabrielle Edwards, Shannon E Rose, Chang-En Yu, Caitlin Latimer, Yu Kitago, Thomas Bird and 3 more
Open access · greenAbstract readPreprint
In one paragraphArticle in bioRxiv : the preprint server for biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literatureWho cites it
0 citing papers in PubMed, 2 citations in OpenAlex.
No citing paper in PubMed yet.
4 · The recordCorrections and comments
5 · Who and what moneyAuthors and funding
13 authors at 4 institutions in 2 countries.
Elnaz FazeliDepartment of Biomedicine, Aarhus University, Høegh-Guldbergs Gade 10, DK8000 AarhusC, Denmark.
Daniel D ChildDepartment of Laboratory Medicine and Pathology, University of Washington, Seattle Washington USA.ORCID 0000-0002-4309-0144 Stephanie A BucksDepartment of Neurology, University of Washington, Seattle Washington USA.
Miki StovarskyDepartment of Medicine, Division of Medical Genetics University of Washington, Seattle Washington USA.
Gabrielle EdwardsDepartment of Neurology, University of Washington, Seattle Washington USA.
Shannon E RoseDepartment of Laboratory Medicine and Pathology, University of Washington, Seattle Washington USA.
Chang-En YuDepartment of Medicine, Division of Medical Genetics University of Washington, Seattle Washington USA.
Caitlin LatimerDepartment of Laboratory Medicine and Pathology, University of Washington, Seattle Washington USA.
Yu KitagoAnn Romney Center for Neurologic Diseases, Harvard Medical School and Brigham and Women's Hospital, Boston, MA 02115.
Thomas BirdDepartment of Neurology, University of Washington, Seattle Washington USA.
Suman JayadevDepartment of Neurology, University of Washington, Seattle Washington USA.
Olav M AndersenDepartment of Biomedicine, Aarhus University, Høegh-Guldbergs Gade 10, DK8000 AarhusC, Denmark.ORCID 0000-0003-4226-3354 Jessica E YoungDepartment of Laboratory Medicine and Pathology, University of Washington, Seattle Washington USA.
University of Washington · USAarhus University · DKUniversity of Washington Medical Center · USBrigham and Women's Hospital · US
Funding
THERAPEUTIC EFFECTS OF INTRA-NASAL INSULIN DETEMIRP50AG005136 · NIA · UNIVERSITY OF WASHINGTON · PI GRABOWSKI, THOMAS J. · 1985 to 2019
$57.2MUniversity of Washington Alzheimer's Disease Research CenterP30AG066509 · NIA · UNIVERSITY OF WASHINGTON · PI Linda K. Ko · 2020 to 2026
$29.0MNeurobehavior, Neuropathology, and Risk Factors in Alzheimer's DiseaseT32AG052354 · NIA · UNIVERSITY OF WASHINGTON · PI Brian C. Kraemer, ELAINE R. PESKIND · 2016 to 2026
$6.7MProbing the role of SORL1 and endosomal network genetic variation on Alzheimer's disease phenotypes in human neurons.R01AG062148 · NIA · UNIVERSITY OF WASHINGTON · PI YOUNG, JESSICA ELAINE · 2018 to 2022
$3.2MMolecular Mechanisms of Synergistic TDP-43 and Tau Proteotoxicity in Alzheimer's DiseaseK08AG065426 · NIA · UNIVERSITY OF WASHINGTON · PI LATIMER, CAITLIN SHANNON · 2020 to 2024
$705kRole of HDAC2 as a modulator of aging and Alzheimer's disease phenotypes in stem-cell derived neuronsK01AG059841 · NIA · UNIVERSITY OF WASHINGTON · PI YOUNG, JESSICA ELAINE · 2019 to 2023
$612kDefining high- and low-risk APOE õ4 haplotypes for AlzheimerâÂÂs diseaseI01BX004823 · VA · VA PUGET SOUND HEALTHCARE SYSTEM · PI YU, CHANG-EN · 2021 to 2025
–BLRD VA I01 BX000933BLRD VA I01 BX004823NIA NIH HHS K01 AG059841NIA NIH HHS K08 AG065426NIA NIH HHS P50 AG005136NIA NIH HHS R01 AG062148NIA NIH HHS T32 AG052354
6 · The paper itselfAbstract
Indexed as
Alzheimer’s diseasepathogenic variantSORL1TDP-43YWTD-domain
Identifiers
PMID37461597
PMCPMC10349966
OpenAlexW4382933883
What OpenQuestion holds
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LicenceCC BY-NC-ND
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