Evidence map›Paper›PMID 37461581›Full record

ArticleResearch square2023

Ketosis Prevents Abdominal Aortic Aneurysm Rupture Through C-C Chemokine Receptor Type 2 Downregulation and Enhanced MMP Balance.

Mohamed Zayed, Sergio Sastriques-Dunlop, Santiago Elizondo-Benedetto, Batool Arif, Rodrigo Meade, Mohamed Zaghloul, Hannah Luehmann, Gyu Heo, Sean English, Yongjian Liu

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in Research square, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 2 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 2 countries.

Mohamed ZayedWashington University in St. Louis School of Medicine.
Sergio Sastriques-DunlopWashington University in St. Louis School of Medicine.
Santiago Elizondo-BenedettoWashington University in St. Louis School of Medicine.
Batool ArifWashington University in St. Louis School of Medicine.
Rodrigo MeadeWashington University in St. Louis School of Medicine.
Mohamed ZaghloulWashington University in St. Louis School of Medicine.
Hannah LuehmannWashington University School of Medicine.
Gyu Heoashington University in St. Louis School of Medicine.
Sean Englishashington University in St. Louis School of Medicine.
Yongjian LiuWash U.
Washington University in St. Louis · USWater Sanitation and Hygiene Institute · IN

Funding

PET Detection of CCR2 in Human AtherosclerosisR01HL150891 · NHLBI · WASHINGTON UNIVERSITY · PI GROPLER, ROBERT J., WOODARD, PAMELA K · 2020 to 2024
$3.7M
CCR2 Targeted Molecular Imaging and Treatment of Abdominal Aortic AneurysmsR01HL153436 · NHLBI · WASHINGTON UNIVERSITY · PI GROPLER, ROBERT J., ZAYED, MOHAMED A. · 2020 to 2023
$3.0M
Regulation of Endothelial Lipid Metabolism in the Setting of Diabetes and Critical Limb Ischemia to Prevent Surgical ComplicationsR01HL153262 · NHLBI · WASHINGTON UNIVERSITY · PI ZAYED, MOHAMED A. · 2021 to 2024
$2.1M
NHLBI NIH HHS R01 HL150891NHLBI NIH HHS R01 HL153262NHLBI NIH HHS R01 HL153436
6 · The paper itself

Abstract

Abdominal aortic aneurysms (AAAs) are prevelant with aging, and AAA rupture is associated with high mortality. There is currently no effective medical therapy for AAA rupture. Previous work demonstrated that the monocyte chemoattractant protein (MCP-1) / C-C chemokine receptor type 2 (CCR2) axis critically regulates AAA inflammation, matrix-metalloproteinase (MMP) production, and extracellular matrix (ECM) stability. Here we similarly observed that

Indexed as

Abdominal Aortic AneurysmAortic InflammationAortic RuptureC-C chemokine receptor 2KetogenesisMatrix-Matalloproteinase

Identifiers

PMID37461581
PMCPMC10350122
OpenAlexW4382537710

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.