Evidence map›Paper›PMID 37461569›Full record

ArticlebioRxiv : the preprint server for biology2023

Microglia-derived TGF-β1 ligand maintains microglia homeostasis via autocrine mechanism and is critical for normal cognitive function in adult mouse brain.

Alicia Bedolla, Elliot Wegman, Max Weed, Aditi Paranjpe, Anastasia Alkhimovitch, Igal Ifergan, Lucas McClain, Yu Luo

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors.

Alicia BedollaDepartment of Molecular and Cellular Biosciences, University of Cincinnati, Cincinnati, OH 45229, USA.
Elliot WegmanDepartment of Molecular and Cellular Biosciences, University of Cincinnati, Cincinnati, OH 45229, USA.
Max WeedDepartment of Molecular and Cellular Biosciences, University of Cincinnati, Cincinnati, OH 45229, USA.
Aditi ParanjpeInformation Services, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA.
Anastasia AlkhimovitchDepartment of Molecular and Cellular Biosciences, University of Cincinnati, Cincinnati, OH 45229, USA.
Igal IferganDepartment of Molecular and Cellular Biosciences, University of Cincinnati, Cincinnati, OH 45229, USA.
Lucas McClainDepartment of Molecular and Cellular Biosciences, University of Cincinnati, Cincinnati, OH 45229, USA.
Yu LuoDepartment of Molecular and Cellular Biosciences, University of Cincinnati, Cincinnati, OH 45229, USA.

Funding

The role TGF-beta Signaling pathway in microglia and astrocytes homeostasis and cellular interactionsR01NS125074 · NINDS · UNIVERSITY OF CINCINNATI · PI Yu Luo · 2022 to 2026
$2.6M
Role of the neurovascular molecule Wnt in regulating CNS inflammatory responsesR35GM146890 · NIGMS · UNIVERSITY OF CINCINNATI · PI Igal Ifergan · 2022 to 2026
$2.2M
Modulating a critical inhibitory proteoglycan receptor to promote functional recovery after strokeR01NS107365 · NINDS · UNIVERSITY OF CINCINNATI · PI LUO, YU, SILVER, JERRY · 2019 to 2022
$1.4M
Leica Stellaris 8 Confocal MicroscopeS10OD030402 · OD · UNIVERSITY OF CINCINNATI · PI HONG, CHRISTIAN I · 2021 to 2021
$598k
Ablating choroid plexus epithelial cells in the developing mouse brain: A new tool to approach CSF disordersR21NS127177 · NINDS · UNIVERSITY OF CINCINNATI · PI GOTO, JUNE, LUO, YU · 2022 to 2022
$457k
The Role of Activin-like kinase 5 (ALK5) for maintaining microglia and astrocyte homeostasis and activationF31NS125930 · NINDS · UNIVERSITY OF CINCINNATI · PI BEDOLLA, ALICIA MARIE · 2022 to 2023
$80k
NIGMS NIH HHS R35 GM146890NIH HHS S10 OD030402NINDS NIH HHS F31 NS125930NINDS NIH HHS R01 NS107365NINDS NIH HHS R01 NS125074NINDS NIH HHS R21 NS127177
6 · The paper itself

Abstract

While TGF-β signaling is essential for microglial function, the cellular source of TGF-β ligand and its spatial regulation remains unclear in the adult CNS. Our data support that microglia, not astrocytes or neurons, are the primary producers of TGF-β1 ligands needed for microglial homeostasis. Microglia (MG)-

Indexed as

agingastrocytescognitive deficitDAMsMicrogliaTGF-beta

Identifiers

PMID37461569
PMCPMC10349967

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.