Evidence map›Paper›PMID 37461564›Full record

ArticlemedRxiv : the preprint server for health sciences2023

Genetic structure of major depression symptoms across clinical and community cohorts.

Mark J Adams, Jackson G Thorp, Bradley S Jermy, Alex S F Kwong, Kadri Kõiv, Andrew D Grotzinger, Michel G Nivard, Sally Marshall, Yuri Milaneschi, Bernhard T Baune and 27 more

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in medRxiv : the preprint server for health sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 3 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

37 authors at 20 institutions in 10 countries.

Mark J AdamsDivision of Psychiatry, University of Edinburgh, Edinburgh, UK.
Jackson G ThorpMental Health and Neuroscience, QIMR Berghofer Medical Research Institute, Brisbane, QLD, AU.
Bradley S JermyInstitute for Molecular Medicine Finland, University of Helsinki, Helsinki, FI.
Alex S F KwongDivision of Psychiatry, University of Edinburgh, Edinburgh, UK.
Kadri KõivEstonian Genome Centre, Institute of Genomics, University of Tartu, Tartu, EE.
Andrew D GrotzingerDepartment of Psychology and Neuroscience, University of Colorado at Boulder, Boulder, CO, US.
Michel G NivardDepartment of Biological Psychology, Vrije Universiteit Amsterdam, Amsterdam, NL.
Sally MarshallCentre for Genomic & Experimental Medicine, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, UK.
Yuri MilaneschiDepartment of Psychiatry, Amsterdam Public Health and Amsterdam Neuroscience, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, NL.
Bernhard T BauneDepartment of Psychiatry, University of Melbourne, Melbourne, VIC, AU.
Bertram Müller-MyhsokDepartment of Translational Research in Psychiatry, Max Planck Institute of Psychiatry, Munich, BY, DE.
Brenda Wjh PenninxDepartment of Psychiatry, Amsterdam Public Health and Amsterdam Neuroscience, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, NL.
Dorret I BoomsmaDepartment of Biological Psychology & Amsterdam Public Health Research Institute, Vrije Universiteit Amsterdam, Amsterdam, NL.
Douglas F LevinsonDepartment of Psychiatry & Behavioral Sciences, Stanford University, Stanford, CA, US.
Gerome BreenSocial, Genetic and Developmental Psychiatry Centre, King's College London, London, UK.
Giorgio PistisDepartment of Psychiatry, Lausanne University Hospital and University of Lausanne, Prilly, VD, CH.
Hans J GrabeDepartment of Psychiatry and Psychotherapy, University Medicine Greifswald, Greifswald MV, DE.
Henning TiemeierChild and Adolescent Psychiatry, Erasmus University Medical Center Rotterdam, Rotterdam, NL.
Klaus BergerInstitute of Epidemiology and Social Medicine, University of Münster, Münster, NRW, DE.
Marcella RietschelDepartment of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, BW, DE.
Patrik K MagnussonDepartment of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, SE.
Rudolf UherPsychiatry, Dalhousie University, Halifax, NS, CA.
Steven P HamiltonPsychiatry, Kaiser Permanente Northern California, San Francisco, CA, US.
Susanne LucaeMax Planck Institute of Psychiatry, Munich, BY, DE.
Kelli LehtoEstonian Genome Centre, Institute of Genomics, University of Tartu, Tartu, EE.
Qingqin S LiNeuroscience Therapeutic Area, Janssen Research and Development, LLC, Titusville, NJ, US.
Enda M ByrneChild Health Research Centre, University of Queensland, Brisbane, QLD, AU.
Ian B HickieBrain and Mind Centre, University of Sydney, Sydney, NSW, AU.
Nicholas G MartinMental Health and Neuroscience, QIMR Berghofer Medical Research Institute, Brisbane, QLD, AU.
Sarah E MedlandMental Health and Neuroscience, QIMR Berghofer Medical Research Institute, Brisbane, QLD, AU.
Naomi R WrayInstitute for Molecular Bioscience, University of Queensland, Brisbane, QLD, AU.
Elliot M Tucker-DrobDepartment of Psychology, University of Texas at Austin, Austin, TX, US.
Estonian Biobank Research Team
Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium
Cathryn M LewisSocial, Genetic and Developmental Psychiatry Centre, King's College London, London, UK.
Andrew M McIntoshDivision of Psychiatry, University of Edinburgh, Edinburgh, UK.
Eske M DerksMental Health and Neuroscience, QIMR Berghofer Medical Research Institute, Brisbane, QLD, AU.
QIMR Berghofer Medical Research Institute · AUAmsterdam Neuroscience · NLKing's College London · GBThe University of Queensland · AUUniversity of Tartu · EEVrije Universiteit Amsterdam · NLDalhousie University · CAEdinburgh Cancer Research · GBGenomics (United Kingdom) · GBHarvard University · USHeidelberg University · DEJanssen (United States) · USKaiser Permanente · USKarolinska Institutet · SEMax Planck Institute of Psychiatry · DEStanford University · USThe University of Melbourne · AUThe University of Sydney · AUThe University of Texas at Austin · USUniversitätsmedizin Greifswald · DE

Funding

Integration of Genomics & Transcriptomics in Normal Twins & Major DepressionRC2MH089951 · NIMH · UNIV OF NORTH CAROLINA CHAPEL HILL · PI SULLIVAN, PATRICK F · 2009 to 2010
$6.5M
Genomics of Developmental Trajectories in TwinsRC2MH089995 · NIMH · UNIVERSITY OF VERMONT & ST AGRIC COLLEGE · PI HUDZIAK, JAMES J. · 2009 to 2010
$3.8M
Dissecting the Multivariate Genetic Architecture of Psychiatric DiseasesR01MH120219 · NIMH · UNIVERSITY OF TEXAS AT AUSTIN · PI NIVARD, MICHEL GUILLAUME, TUCKER-DROB, ELLIOT MAX · 2020 to 2024
$3.3M
7/7 Psychiatric Genomics Consortium: Finding actionable variationU01MH109532 · NIMH · WASHINGTON UNIVERSITY · PI AGRAWAL, ARPANA, EDENBERG, HOWARD J · 2016 to 2020
$3.1M
1/7 Psychiatric Genomics Consortium: Finding actionable variationU01MH109528 · NIMH · UNIV OF NORTH CAROLINA CHAPEL HILL · PI SULLIVAN, PATRICK F · 2016 to 2020
$2.5M
1/4 Psychiatric GWAS Consortium: Genomic Follow-up Next-Gen Sequencing & GenotypiU01MH094421 · NIMH · UNIV OF NORTH CAROLINA CHAPEL HILL · PI SULLIVAN, PATRICK F · 2012 to 2015
$1.9M
1/5-The Psychiatric GWAS Consortium: Integrated & Coordinated GWAS Meta-AnalysesU01MH085520 · NIMH · UNIV OF NORTH CAROLINA CHAPEL HILL · PI SULLIVAN, PATRICK F · 2008 to 2008
$642k
Major Depression: Stage 1 Genomewide Association in Population-Based SamplesR01MH081802 · NIMH · UNIV OF NORTH CAROLINA CHAPEL HILL · PI SULLIVAN, PATRICK F · 2007 to 2007
$138k
NIMH NIH HHS R01 MH081802NIMH NIH HHS R01 MH120219NIMH NIH HHS RC2 MH089951NIMH NIH HHS RC2 MH089995NIMH NIH HHS U01 MH085520NIMH NIH HHS U01 MH094421NIMH NIH HHS U01 MH109528NIMH NIH HHS U01 MH109532Wellcome Trust
6 · The paper itself

Abstract

Diagnostic criteria for major depressive disorder allow for heterogeneous symptom profiles but genetic analysis of major depressive symptoms has the potential to identify clinical and aetiological subtypes. There are several challenges to integrating symptom data from genetically-informative cohorts, such as sample size differences between clinical and community cohorts and various patterns of missing data. We conducted genome-wide association studies of major depressive symptoms in three clinical cohorts that were enriched for affected participants (Psychiatric Genomics Consortium, Australian Genetics of Depression Study, Generation Scotland) and three community cohorts (Avon Longitudinal Study of Parents and Children, Estonian Biobank, and UK Biobank). We fit a series of confirmatory factor models with factors that accounted for how symptom data was sampled and then compared alternative models with different symptom factors. The best fitting model had a distinct factor for

Identifiers

PMID37461564
PMCPMC10350129
OpenAlexW4383500293

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.