Evidence map›Paper›PMID 37461561›Full record

ArticlebioRxiv : the preprint server for biology2023

Molecular recognition of an aversive odorant by the murine trace amine-associated receptor TAAR7f.

Anastasiia Gusach, Yang Lee, Armin Nikpour Khoshgrudi, Elizaveta Mukhaleva, Ning Ma, Eline J Koers, Qingchao Chen, Patricia C Edwards, Fanglu Huang, Jonathan Kim and 5 more

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 2 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

15 authors at 6 institutions in 2 countries.

Anastasiia GusachMRC Laboratory of Molecular Biology, Francis Crick Avenue, Cambridge CB2 0QH, UK.
Yang LeeMRC Laboratory of Molecular Biology, Francis Crick Avenue, Cambridge CB2 0QH, UK.
Armin Nikpour KhoshgrudiCentre of Membrane Proteins and Receptors (COMPARE), University of Birmingham and University of Nottingham, Midlands, NG7 2RD, UK.
Elizaveta MukhalevaDepartment of Computational and Quantitative Medicine, Beckman Research Institute of the City of Hope, 1500 E Duarte Road, Duarte, CA-91006, USA.
Ning MaDepartment of Computational and Quantitative Medicine, Beckman Research Institute of the City of Hope, 1500 E Duarte Road, Duarte, CA-91006, USA.
Eline J KoersCentre of Membrane Proteins and Receptors (COMPARE), University of Birmingham and University of Nottingham, Midlands, NG7 2RD, UK.
Qingchao ChenMRC Laboratory of Molecular Biology, Francis Crick Avenue, Cambridge CB2 0QH, UK.
Patricia C EdwardsMRC Laboratory of Molecular Biology, Francis Crick Avenue, Cambridge CB2 0QH, UK.
Fanglu HuangDepartment of Biochemistry, University of Cambridge, Tennis Court Road, Cambridge, UK.
Jonathan KimDepartment of Physiology and Cellular Biophysics, Columbia University, Irving Medical Center, New York, NY 10032, USA.
Filippo ManciaDepartment of Physiology and Cellular Biophysics, Columbia University, Irving Medical Center, New York, NY 10032, USA.
Dmitry B VerprintsevCentre of Membrane Proteins and Receptors (COMPARE), University of Birmingham and University of Nottingham, Midlands, NG7 2RD, UK.
Nagarajan VaidehiDepartment of Computational and Quantitative Medicine, Beckman Research Institute of the City of Hope, 1500 E Duarte Road, Duarte, CA-91006, USA.
Simone N WeyandDepartment of Biochemistry, University of Cambridge, Tennis Court Road, Cambridge, UK.
Christopher G TateMRC Laboratory of Molecular Biology, Francis Crick Avenue, Cambridge CB2 0QH, UK.
MRC Laboratory of Molecular Biology · GBCity of Hope · USUniversity of Nottingham · GBColumbia University Irving Medical Center · USEuropean Bioinformatics Institute · GBUniversity of Cambridge · GB

Funding

Structural dynamics underlying GPCR-G protein selectivityR01GM117923 · NIGMS · BECKMAN RESEARCH INSTITUTE/CITY OF HOPE · PI VAIDEHI, NAGARAJAN · 2017 to 2024
$3.8M
Structural basis of integral membrane enzyme functionR35GM132120 · NIGMS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI Filippo Mancia · 2019 to 2026
$3.7M
An integrated toolkit combining computational systems biology techniques with molecular dynamics simulations to delineate functionality of GPCRsR01LM013876 · NLM · BECKMAN RESEARCH INSTITUTE/CITY OF HOPE · PI RODIN, ANDREI, VAIDEHI, NAGARAJAN · 2022 to 2025
$1.5M
NIGMS NIH HHS R01 GM117923NIGMS NIH HHS R35 GM132120NLM NIH HHS R01 LM013876Wellcome Trust
6 · The paper itself

Abstract

There are two main families of G protein-coupled receptors that detect odours in humans, the odorant receptors (ORs) and the trace amine-associated receptors (TAARs). Their amino acid sequences are distinct, with the TAARs being most similar to the aminergic receptors such as those activated by adrenaline, serotonin and histamine. To elucidate the structural determinants of ligand recognition by TAARs, we have determined the cryo-EM structure of a murine receptor, mTAAR7f, coupled to the heterotrimeric G protein G

Identifiers

PMID37461561
PMCPMC10350033
OpenAlexW4383501025

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.