Evidence map›Paper›PMID 37461519›Full record

ArticleResearch square2023

An enteroendocrine-microbial axis in the large intestine controls host metabolism.

Shuai Tan, Jacobo Santolaya, Tiffany Freeney Wright, Qi Liu, Teppei Fujikawa, Sensen Chi, Colin P Bergstrom, Adam Lopez, Qing Chen, Goncalo Dias do Vale and 5 more

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in Research square, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

15 authors at 5 institutions in 2 countries.

Shuai TanDepartment of Immunology, School of Basic Medical Sciences, Chongqing Medical University, Chongqing 400010, China.
Jacobo SantolayaDepartment of Pediatrics, The University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
Tiffany Freeney WrightDepartment of Pediatrics, The University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
Qi LiuDepartment of Internal Medicine, The University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
Teppei FujikawaDivision of Hypothalamic Research, Department of Internal Medicine, The University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
Sensen ChiDepartment of Immunology, School of Basic Medical Sciences, Chongqing Medical University, Chongqing 400010, China.
Colin P BergstromDepartment of Internal Medicine, The University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
Adam LopezDepartment of Internal Medicine, The University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
Qing ChenDepartment of Internal Medicine, The University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
Goncalo Dias do ValeDepartment of Molecular Genetics, The University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.ORCID 0000-0003-1104-0289
Jeffrey G McDonaldDepartment of Molecular Genetics, The University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.ORCID 0000-0003-1570-4142
Da JiaKey Laboratory of Birth Defects and Related Diseases of Women and Children, Department of Paediatrics, West China Second University Hospital, State Key Laboratory of Biotherapy and Collaborative Innovation Center of Biotherapy, Sichuan University, Chengdu 610041, China.ORCID 0000-0002-2205-1998
Joel K ElmquistDivision of Hypothalamic Research, Department of Internal Medicine, The University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
Luis Sifuentes-DominguezDepartment of Pediatrics, The University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
Ezra BursteinDepartment of Internal Medicine, The University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
The University of Texas Southwestern Medical Center · USChongqing Medical University · CNSichuan University · CNSouthwestern Medical CenterSouthwestern Medical Center · US

Funding

Ventromedial Hypothalamic Regulation of Metabolic Changes Induced by ExerciseP01DK119130 · NIDDK · UT SOUTHWESTERN MEDICAL CENTER · PI GAUTRON, LAURENT · 2019 to 2023
$10.0M
UT GASTROENTEROLOGY/HEPATOLOGY RESEARCH TRAINING PROGRAMT32DK007745 · NIDDK · UT SOUTHWESTERN MEDICAL CENTER · PI Rodney E Infante · 1997 to 2026
$6.8M
Metabolic Benefits of Leptin ReductionR01DK127274 · NIDDK · UT SOUTHWESTERN MEDICAL CENTER · PI JOEL K. ELMQUIST, PHILIPP E SCHERER · 2021 to 2026
$5.1M
SF1 neurons and sympathetic regulation of glucose homeostasisR01DK100659 · NIDDK · UT SOUTHWESTERN MEDICAL CENTER · PI JOEL K. ELMQUIST · 2014 to 2026
$4.8M
Role of colonic enteroendocrine cells in metabolic controlR01DK130957 · NIDDK · UT SOUTHWESTERN MEDICAL CENTER · PI BURSTEIN, EZRA · 2022 to 2025
$2.3M
Role of SCGN in Intestinal Immune HomeostasisK08DK127197 · NIDDK · UT SOUTHWESTERN MEDICAL CENTER · PI SIFUENTES-DOMINGUEZ, LUIS · 2021 to 2024
$670k
NIDDK NIH HHS K08 DK127197NIDDK NIH HHS P01 DK119130NIDDK NIH HHS R01 DK100659NIDDK NIH HHS R01 DK127274NIDDK NIH HHS R01 DK130957NIDDK NIH HHS T32 DK007745
6 · The paper itself

Abstract

Nutrient handling is an essential function of the gastrointestinal tract. Most nutrient absorption occurs in the small intestine and is coordinated by hormone-producing intestinal epithelial cells known as enteroendocrine cells (EECs)

Identifiers

PMID37461519
PMCPMC10350199
OpenAlexW4383377698

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.