Evidence map›Paper›PMID 37461476›Full record

ArticlemedRxiv : the preprint server for health sciences2023

A 3'UTR Insertion Is a Candidate Causal Variant at the

Augustine Chemparathy, Yann Le Guen, Yi Zeng, John Gorzynski, Tanner Jensen, Chengran Yang, Nandita Kasireddy, Lia Talozzi, Michael E Belloy, Ilaria Stewart and 8 more

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in medRxiv : the preprint server for health sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 11 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

18 authors at 3 institutions in 1 country.

Augustine ChemparathyDepartment of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA.
Yann Le GuenDepartment of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA.
Yi ZengDepartment of Genetics, Stanford University School of Medicine, Stanford, CA.
John GorzynskiDepartment of Genetics, Stanford University School of Medicine, Stanford, CA.
Tanner JensenDepartment of Genetics, Stanford University School of Medicine, Stanford, CA.
Chengran YangNeurogenomics and Informatics Center, Washington University School of Medicine, St. Louis, MO.
Nandita KasireddyDepartment of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA.
Lia TalozziDepartment of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA.
Michael E BelloyDepartment of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA.
Ilaria StewartDepartment of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA.
Aaron D GitlerDepartment of Genetics, Stanford University School of Medicine, Stanford, CA.
Anthony D WagnerWu Tsai Neurosciences Institute, Stanford University, Stanford, CA, USA.
Elizabeth MorminoWu Tsai Neurosciences Institute, Stanford University, Stanford, CA, USA.
Victor W HendersonDepartment of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA.
Tony Wyss-CorayDepartment of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA.
Euan AshleyDepartment of Genetics, Stanford University School of Medicine, Stanford, CA.
Carlos CruchagaNeurogenomics and Informatics Center, Washington University School of Medicine, St. Louis, MO.ORCID 0000-0002-0276-2899
Michael D GreiciusDepartment of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA.
Stanford University · USNeurosciences Institute · USWashington University in St. Louis · US

Funding

Smartphone-Based "Burst" Cognitive AssessmentsP01AG003991 · NIA · WASHINGTON UNIVERSITY · PI Tammie Lee Smith Benzinger · 1985 to 2026
$69.5M
The natural history of AB accumulation in preclinical ADP01AG026276 · NIA · WASHINGTON UNIVERSITY · PI MORRIS, JOHN · 2005 to 2025
$49.5M
INSTITUTIONAL TRAINING GRANT IN GENOME SCIENCET32HG000044 · NHGRI · STANFORD UNIVERSITY · PI MICHAEL P. SNYDER · 1995 to 2026
$32.2M
Stanford Alzheimer's Disease Research CenterAdmin Supp: Developing iPSC models for AD and PDP30AG066515 · NIA · STANFORD UNIVERSITY · PI ELIZABETH MORMINO · 2020 to 2026
$29.0M
Research Education ComponentP30AG066444 · NIA · WASHINGTON UNIVERSITY · PI DAVID M. HOLTZMAN · 2020 to 2026
$28.7M
Hippocampal-dependent memory decline in aging and early Alzheimer's diseaseR01AG074339 · NIA · STANFORD UNIVERSITY · PI ELIZABETH MORMINO · 2022 to 2026
$6.0M
Illuminating the APOE Locus with Long-Read Sequencing and Targeted GenomicsR35AG072290 · NIA · STANFORD UNIVERSITY · PI GREICIUS, MICHAEL D · 2021 to 2025
$4.6M
USING QUANTITATIVE TRAITS TO IDENTIFY NOVEL GENES FOR ALZHEIMERS DISEASE AND OTHER COMPLEX TRAITSRF1AG053303 · NIA · WASHINGTON UNIVERSITY · PI CLIMER, SHARLEE, CRUCHAGA, CARLOS · 2016 to 2020
$4.0M
GENETIC MODIFIERS OF CEREBROSPINAL FLUID TREM2 IN ALZHEIMER'S DISEASERF1AG058501 · NIA · WASHINGTON UNIVERSITY · PI CRUCHAGA, CARLOS, PICCIO, LAURA · 2018 to 2018
$3.5M
The Familial Alzheimer Sequencing (FASe) ProjectU01AG058922 · NIA · WASHINGTON UNIVERSITY · PI CRUCHAGA, CARLOS, GOATE, ALISON M · 2018 to 2022
$3.5M
The Stanford Extreme Phenotypes in Alzheimer's Disease (StEP AD) CohortR01AG060747 · NIA · STANFORD UNIVERSITY · PI GREICIUS, MICHAEL D · 2018 to 2022
$3.4M
Sex-specific Molecular Profiling to Understand Pathology and Identify Causal Genes and Drug Targets for Alzheimer's DiseaseRF1AG074007 · NIA · WASHINGTON UNIVERSITY · PI SUNG, YUNJU · 2021 to 2021
$2.7M
Austrian Science Fund FWF I 904NHGRI NIH HHS T32 HG000044NIA NIH HHS K99 AG075238NIA NIH HHS P01 AG003991NIA NIH HHS P01 AG026276NIA NIH HHS P30 AG066444NIA NIH HHS P30 AG066515NIA NIH HHS R00 AG075238NIA NIH HHS R01 AG044546NIA NIH HHS R01 AG048076NIA NIH HHS R01 AG060747NIA NIH HHS R01 AG074339NIA NIH HHS R35 AG072290NIA NIH HHS RF1 AG053303NIA NIH HHS RF1 AG058501NIA NIH HHS RF1 AG074007NIA NIH HHS U01 AG058922
6 · The paper itself

Abstract

Background and Objectives: Single nucleotide variants near Methods: An exploratory analysis identified structural variants on neurodegeneration-related genes. Subsequent analyses focused on an Results: The primary analysis included 432 participants (52.5% females, age range 45-92 years old). We identified a 316 bp Discussion: We identified a novel

Identifiers

PMID37461476
PMCPMC10350161
OpenAlexW4383646087

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.