Evidence map›Paper›PMID 37461364›Full record

ReviewCNS & neurological disorders drug targets2024

Therapeutic Potential of Myricetin in the Treatment of Neurological, Neuropsychiatric, and Neurodegenerative Disorders.

Neeraj Kumar Sethiya, Neha Ghiloria, Akanksha Srivastav, Dheeraj Bisht, Sushil Kumar Chaudhary, Vaibhav Walia, Md Sabir Alam

Abstract readReview
PubMed Publisher
In one paragraph

Review in CNS & neurological disorders drug targets, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
  4. Review
  5. Review
  6. Eco-friendly Synthesis ofPharmaceutical nanotechnology · 2025
    Review
  7. Review
  8. Article
  9. Sirtuins as Players in the Signal Transduction ofInternational journal of molecular sciences · 2024
    Review
  10. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Neeraj Kumar SethiyaFaculty of Pharmacy, DIT University Dehradun, Uttarakhand 248009, India.ORCID 0000-0002-0192-1384
Neha GhiloriaDr. Baba Saheb Ambedkar Hospital, Rohini, New Delhi 110085, India.
Akanksha SrivastavFaculty of Pharmacy, DIT University Dehradun, Uttarakhand 248009, India.
Dheeraj BishtDepartment of Pharmaceutical Sciences, Sir J.C. Bose Technical Campus, Bhimtal, Kumaun University, Nainital, Uttarakhand 263002, India.ORCID 0000-0002-8049-6178
Sushil Kumar ChaudharyInstitute of Bioresources and Sustainable Development, Imphal, Manipur 795001, India.
Vaibhav WaliaDepartment of Pharmacology, SGT College of Pharmacy, SGT University, Gurugram, Haryana 122505, India.ORCID 0000-0002-6043-3495
Md Sabir AlamDepartment of Pharmaceutics, SGT College of Pharmacy, SGT University, Gurugram, Haryana 122505, India.ORCID 0000-0002-2845-0156

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Myricetin (MC), 3,5,7,3',4',5'-hexahydroxyflavone, chemically belongs to a flavonoid category known to confer antioxidant, antimicrobial, antidiabetic, and neuroprotective effects. MC is known to suppress the generation of Reactive Oxygen Species (ROS), lipid peroxidation (MDA), and inflammatory markers. It has been reported to improve insulin function in the human brain and periphery. Besides this, it modulates several neurochemicals including glutamate, GABA, serotonin, etc. MC has been shown to reduce the expression of the enzyme Mono Amine Oxidase (MAO), which is responsible for the metabolism of monoamines. MC treatment reduces levels of plasma corticosterone and restores hippocampal BDNF (full form) protein in stressed animals. Further, MC has shown its protective effect against amyloid-beta, MPTP, rotenone, 6-OHDA, etc. suggesting its potential role against neurodegenerative disorders. The aim of the present review is to highlight the therapeutic potential of MC in the treatment of several neurological, neuropsychiatric, and neurodegenerative disorders.

Indexed as

FlavonoidsNeurodegenerative DiseasesNeuroprotective AgentsAnimalsAntioxidantsHumansMental DisordersNervous System DiseasesAntioxidantsFlavonoidsmyricetinNeuroprotective Agentsacetylcholine.Alzheimer’sanxietydepressionHuntington’s diseaseMyricetinParkinson’s diseasestroke

Identifiers

PMID37461364

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.