Evidence map›Paper›PMID 37461351›Full record

ArticlePharmaceutical nanotechnology2024

Folate-mediated Transport of Nanoparticles across the Placenta.

Irina Kalashnikova, Svetlana Patrikeeva, Tatiana N Nanovskaya, Yaroslav A Andreev, Mahmoud S Ahmed, Erik Rytting

Abstract read
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In one paragraph

Article in Pharmaceutical nanotechnology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Irina KalashnikovaDepartment of Obstetrics and Gynecology, University of Texas Medical Branch, Galveston, TX, USA.
Svetlana PatrikeevaDepartment of Obstetrics and Gynecology, University of Texas Medical Branch, Galveston, TX, USA.
Tatiana N NanovskayaDepartment of Obstetrics and Gynecology, University of Texas Medical Branch, Galveston, TX, USA.
Yaroslav A AndreevInstitute of Molecular Medicine, I.M. Sechenov First Moscow State Medical University, 119991 Moscow, Russia.
Mahmoud S AhmedDepartment of Obstetrics and Gynecology, University of Texas Medical Branch, Galveston, TX, USA.
Erik RyttingDepartment of Obstetrics and Gynecology, University of Texas Medical Branch, Galveston, TX, USA.

Funding

UTMB WOMEN'S HEALTH RESEARCH SCHOLARS PROGRAMK12HD052023 · NICHD · UNIVERSITY OF TEXAS MEDICAL BR GALVESTON · PI BERENSON, ABBEY B · 2005 to 2023
$8.1M
NICHD NIH HHS K12 HD052023
6 · The paper itself

Abstract

backgroundIn this study, a prototype of a targeted nanocarrier for drug delivery for prenatal therapy of the developing fetus was developed and examined

methodsSeveral types of folic acid-decorated polymeric nanoparticles were synthesized and characterized. During transport studies of targeted and non-targeted fluorescent nanoparticles across the placental barrier, the apparent permeability values, uptake, transfer indices, and distribution in placental tissue were determined.

resultsThe nanoparticles had no effect on BeWo b30 cell viability.

conclusionThe data obtained suggested different mechanisms for the uptake and transplacental transfer of targeted

Indexed as

Folic AcidNanoparticlesPlacentaBiological TransportCell Line, TumorCell SurvivalDrug CarriersFemaleHumansPolyethylene GlycolsPregnancyDrug CarriersFolic AcidPolyethylene Glycolsfolate receptors.folic acidNanomedicineplacentaPLGA nanoparticlestargeted drug delivery

Identifiers

PMID37461351

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.