Evidence map›Paper›PMID 37461344›Full record

ArticleCombinatorial chemistry & high throughput screening2024

Protective Effects of Liriodendrin on Myocardial Infarction-Induced Fibrosis in Rats

Ping Zhang, Xuanming Liu, Xin Yu, Yuzhen Zhuo, Dihua Li, Lei Yang, Yanmin Lu

Abstract read
PubMed Publisher
In one paragraph

Article in Combinatorial chemistry & high throughput screening, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Signaling Pathways and Therapeutic Approaches in Post-Myocardial Infarction Fibrosis.Medical science monitor : international medical journal of experimental and clinical research · 2025
    Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Ping ZhangDepartment of Cardiology, Tianjin Nankai Hospital, Tianjin, 300100, China.
Xuanming LiuGraduate School, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China.
Xin YuGraduate School, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China.
Yuzhen ZhuoTianjin Key Laboratory of Acute Abdomen Disease Associated Organ Injury and ITCWM Repair, Tianjin Nankai Hospital, Tianjin, 300100, China.
Dihua LiTianjin Key Laboratory of Acute Abdomen Disease Associated Organ Injury and ITCWM Repair, Tianjin Nankai Hospital, Tianjin, 300100, China.
Lei YangTianjin Key Laboratory of Acute Abdomen Disease Associated Organ Injury and ITCWM Repair, Tianjin Nankai Hospital, Tianjin, 300100, China.
Yanmin LuTianjin Key Laboratory of Acute Abdomen Disease Associated Organ Injury and ITCWM Repair, Tianjin Nankai Hospital, Tianjin, 300100, China.

Funding

National Natural Science Foundation of China 81801949National Natural Science Foundation of Tianjin 18JCQNJC13400science foundation of Tianjin Municipal Health Bureau, China 2021044
6 · The paper itself

Abstract

backgroundLiriodendrin (LIR) has been reported to improve cardiac function in rats following myocardial infarction. However, its role and mechanism in reparative myocardial fibrosis remain unclear.

methodsIn this study, a rat model of myocardial fibrosis was established

resultsOur findings demonstrated that LIR improved cardiac function, histology scores, and col lagen volume fraction. Moreover, LIR downregulated the expression of Beclin-1, LC3-II/LC3-I while upregulating the expression of p62, indicating LIR-inhibited autophagy in the heart after myocardial infarction. Further analysis revealed that the PI3K/Akt signaling pathway was significantly enriched and validated by western blot. This analysis suggested that the ratios of p- PI3K/PI3K, p-Akt/Akt, and p-mTOR/mTOR were significantly increased.

conclusionLIR may attenuate myocardial infarction-induced fibrosis in rats by inhibiting excessive myocardial autophagy, with the potential mechanism involving the activation of the PI3K/Akt/mTOR pathway.

Indexed as

AutophagyFibrosisMyocardial InfarctionNetwork PharmacologyPhosphatidylinositol 3-KinasesProto-Oncogene Proteins c-aktRats, Sprague-DawleyAnimalsMaleRatsSignal TransductionPhosphatidylinositol 3-KinasesProto-Oncogene Proteins c-aktAutophagyliriodendrinmyocardial fibrosismyocardial infarction (MI).network pharmacologyPI3K-Akt signaling pathway

Identifiers

PMID37461344

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.