ArticleHuman brain mapping2023
Mapping tissue microstructure across the human brain on a clinical scanner with soma and neurite density image metrics.
Article in Human brain mapping, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 31 citations in OpenAlex.
- Electroconvulsive therapy induces rapid microstructural and macrostructural changes, but microstructural changes are longer-lasting.European archives of psychiatry and clinical neuroscience · 2026Trial
- Clinical Soma and Neurite Density Imaging (SANDI): Translational Microstructure Mapping on Clinical 3T MRI Scanners.Magnetic resonance in medicine · 2026Article
- Dependence of the Extra-Cellular Diffusion Coefficient on the Fractions of Neurites and Cell Bodies in Gray Matter.Magnetic resonance in medicine · 2026Article
- Comparative Systematic Analysis of Gray Matter Biophysical Models on a Public Dataset.Magnetic resonance in medicine · 2026Article
- In vivo mapping of striatal neurodegeneration in Huntington's disease with Soma and Neurite Density Imaging.eLife · 2026Article
- Invisible neuronal damage in stroke-free, asymptomatic chronic middle cerebral artery occlusion: evidence from soma and neurite density imaging.European radiology · 2026Article
- Cortical mean diffusivity detects early age-related changes and associates with cognition and plasma biomarkers.Brain communications · 2026Article
- Validating the neurite exchange imaging (NEXI) model of gray matter using Monte Carlo simulations in numerical substrates.Imaging neuroscience (Cambridge, Mass.) · 2026Article
- Diffusion Basis Restricted Fraction as a Putative Magnetic Resonance Imaging Marker of Neuroinflammation: Histological Evidence, Diagnostic Accuracy, and Translational Potential.Life (Basel, Switzerland) · 2025Review
- Longitudinal changes in cortical cell body and neurite density in people with multiple sclerosis.Neuroscience · 2025Article
- Evaluating the impact of denoising diffusion MRI data on tractometry metrics of optic tract abnormalities in glaucoma.Scientific reports · 2025Article
- In vivo cortical microstructure mapping using high-gradient diffusion MRI accounting for intercompartmental water exchange effects.NeuroImage · 2025Article
- MRI signatures of cortical microstructure in human development align with oligodendrocyte cell-type expression.Nature communications · 2025Article
- Soma and neurite density abnormalities of paramagnetic rim lesions and core-sign lesions in multiple sclerosis.Journal of neurology · 2025Article
- Human gray matter microstructure mapped using neurite exchange imaging (NEXI) on a clinical scanner.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- Characterization of neurite and soma organization in the brain and spinal cord with diffusion MRI.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- In vivo evidence for cell body loss in cortical lesions in people with multiple sclerosis.Annals of clinical and translational neurology · 2025Article
- Age-related alterations in human cortical microstructure across the lifespan: Insights from high-gradient diffusion MRI.Aging cell · 2024Article
- Intrinsic and extrinsic contributors to subregional thalamic volume loss in multiple sclerosis.Annals of clinical and translational neurology · 2024Article
- Mapping tissue microstructure across the human brain on a clinical scanner with soma and neurite density image metrics.Human brain mapping · 2023Article
Corrections and comments
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Authors and funding
8 authors at 5 institutions in 3 countries.
Funding
Abstract
Soma and neurite density image (SANDI) is an advanced diffusion magnetic resonance imaging biophysical signal model devised to probe in vivo microstructural information in the gray matter (GM). This model requires acquisitions that include b values that are at least six times higher than those used in clinical practice. Such high b values are required to disentangle the signal contribution of water diffusing in soma from that diffusing in neurites and extracellular space, while keeping the diffusion time as short as possible to minimize potential bias due to water exchange. These requirements have limited the use of SANDI only to preclinical or cutting-edge human scanners. Here, we investigate the potential impact of neglecting water exchange in the SANDI model and present a 10-min acquisition protocol that enables to characterize both GM and white matter (WM) on 3 T scanners. We implemented analytical simulations to (i) evaluate the stability of the fitting of SANDI parameters when diminishing the number of shells; (ii) estimate the bias due to potential exchange between neurites and extracellular space in such reduced acquisition scheme, comparing it with the bias due to experimental noise. Then, we demonstrated the feasibility and assessed the repeatability and reproducibility of our approach by computing microstructural metrics of SANDI with AMICO toolbox and other state-of-the-art models on five healthy subjects. Finally, we applied our protocol to five multiple sclerosis patients. Results suggest that SANDI is a practical method to characterize WM and GM tissues in vivo on performant clinical scanners.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.