ArticleBMC complementary medicine and therapies2023
Repurposing drugs to treat trichinellosis: in vitro analysis of the anthelmintic activity of nifedipine and Chrysanthemum coronarium extract.
Article in BMC complementary medicine and therapies, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed.
- Naringenin mitigates experimental Trichinella spiralis infection in in vitro and in vivo studies.Scientific reports · 2026Article
- Evaluation of the Efficacy of Anthelmintic Drugs AgainstAntibiotics (Basel, Switzerland) · 2026Article
- Staphyloxanthin loaded niosomal nanocarrier augments its anthelmintic activity against Trichinella spiralis infection in mice.Scientific reports · 2025Article
- Anticestodial Efficacy and GC-MS Study of Evolvulus nummularius, a Traditionally Used Anthelmintic Plant of North-East India.Acta parasitologica · 2025Article
- Article
- AxiWorm: a new tool using YOLOv5 to test antiparasitic drugs against Trichinella spiralis.Parasites & vectors · 2025Article
- Bio-fabricated zinc oxide nanoparticles mediated by endophytic fungusFrontiers in microbiology · 2024Article
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6 authors.
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Abstract
Albendazole is the most common benzimidazole derivative used for trichinellosis treatment but has many drawbacks. The quest for alternative compounds is, therefore, a target for researchers. This work aims to assess the in vitro anthelmintic effect of nifedipine, a calcium channel blocker, and a methanol extract of the flowers of Chrysanthemum coronarium as therapeutic repurposed drugs for treating different developmental stages of Trichinella spiralis in comparison with the reference drug, albendazole. Adult worms and muscle larvae of Trichinella spiralis were incubated with different concentrations of the studied drugs. Drug effects were evaluated by parasitological and electron microscopic examination.As a result, the effects of these drugs on muscle larvae were time and dose-dependent. Moreover, the LC
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