Evidence map›Paper›PMID 37460847›Full record

ArticleMolecular psychiatry2023

Poorer aging trajectories are associated with elevated serotonin synthesis capacity.

Teodora Z Markova, Claire J Ciampa, Jourdan H Parent, Molly R LaPoint, Mark D'Esposito, William J Jagust, Anne S Berry

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular psychiatry, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.2field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 7 citations in OpenAlex.

  1. Review
  2. Trajectories of late-life depression: insights from molecular imaging.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026
    Review
  3. Sex differences in neuromodulatory subcortical systems and their implications for Alzheimer's disease.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026
    Review
  4. Review
  5. Defining the contributions of tau pathology in the amygdala to increasing depressive symptoms in aging.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025
    Article
  6. Article
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Teodora Z MarkovaBrandeis University, Waltham, MA, 02453, USA. teodoramarkova@brandeis.edu.ORCID 0009-0004-7178-6976
Claire J CiampaBrandeis University, Waltham, MA, 02453, USA.
Jourdan H ParentBrandeis University, Waltham, MA, 02453, USA.
Molly R LaPointHelen Wills Neuroscience Institute, University of California Berkeley, Berkeley, CA, 94720, USA.
Mark D'EspositoHelen Wills Neuroscience Institute, University of California Berkeley, Berkeley, CA, 94720, USA.ORCID 0000-0002-3462-006X
William J JagustHelen Wills Neuroscience Institute, University of California Berkeley, Berkeley, CA, 94720, USA.ORCID 0000-0002-4458-113X
Anne S BerryBrandeis University, Waltham, MA, 02453, USA.ORCID 0000-0002-5086-3643
Brandeis University · USUniversity of California, Berkeley · USLawrence Berkeley National Laboratory · US

Funding

Neural and Biochemical Mechanisms of Cognitive AgingR01AG034570 · NIA · UNIVERSITY OF CALIF-LAWRENC BERKELEY LAB · PI William J. Jagust · 2009 to 2026
$12.0M
Upregulated Norepinephrine Synthesis Capacity in AgingR01AG074330 · NIA · BRANDEIS UNIVERSITY · PI Anne Shively Berry · 2022 to 2026
$6.2M
Mechanisms of Alzheimer's Disease Progression in the Aging BrainR01AG062542 · NIA · UNIVERSITY OF CALIF-LAWRENC BERKELEY LAB · PI JAGUST, WILLIAM J. · 2019 to 2023
$4.2M
Aging Brain, Cognition, and DopamineR01AG044292 · NIA · UNIVERSITY OF CALIF-LAWRENC BERKELEY LAB · PI JAGUST, WILLIAM J. · 2013 to 2017
$3.6M
Dopamine and Frontostriatal FunctionR01DA034685 · NIDA · UNIVERSITY OF CALIFORNIA BERKELEY · PI D'ESPOSITO, MARK · 2013 to 2017
$3.4M
Age effects on memory and reward systems in decision makingR00AG058748 · NIA · BRANDEIS UNIVERSITY · PI BERRY, ANNE SHIVELY · 2019 to 2021
$745k
Locus Coeruleus Biomarker Development for Early Detection of Alzheimers Disease in HumansR03AG072328 · NIA · BRANDEIS UNIVERSITY · PI BERRY, ANNE SHIVELY · 2021 to 2022
$325k
Age effects on memory and reward systems in decision makingK99AG058748 · NIA · UNIVERSITY OF CALIF-LAWRENC BERKELEY LAB · PI BERRY, ANNE SHIVELY · 2018 to 2019
$250k
Alzheimer's Association AARF-17-530186NIA NIH HHS K99 AG058748NIA NIH HHS R00 AG058748NIA NIH HHS R01 AG034570NIA NIH HHS R01 AG044292NIA NIH HHS R01 AG062542NIA NIH HHS R01 AG074330NIA NIH HHS R03 AG072328NIDA NIH HHS R01 DA034685
6 · The paper itself

Abstract

The dorsal raphe nucleus (DRN) is one of the earliest targets of Alzheimer's disease-related tau pathology and is a major source of brain serotonin. We used [

Indexed as

Alzheimer DiseaseCognitive DysfunctionAdolescentAdultAgedAged, 80 and overAgingAmyloid beta-PeptidesAtrophyCross-Sectional StudiesFemaleHumansMagnetic Resonance ImagingMiddle AgedPositron-Emission TomographySerotoninAmyloid beta-PeptidesSerotonintau Proteins

Identifiers

PMID37460847
PMCPMC10792105
OpenAlexW4384559064

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.