ArticleNature ecology & evolution2023
Convergent resistance to GABA receptor neurotoxins through plant-insect coevolution.
Article in Nature ecology & evolution, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 42 citations in OpenAlex.
- Multimodal targets of (-)-α-thujone mediating avoidance behavior of a stored-products pest, Tribolium castaneum, in response to irritant stimuli.Pest management science · 2026Article
- Horizontal gene transfer rivals gene duplication as a source of anti-parasitoid immune innovation in the Drosophilidae.bioRxiv : the preprint server for biology · 2026Article
- Association of Different Host Diets with the Nutritional Composition of the Fall Webworm,Insects · 2026Article
- Epistasis among clustered lineage-specific amino acid substitutions in the Drosophila Trio protein.PLoS genetics · 2026Article
- Genome-wide association studies identify new candidate genes and tissues underlying resistance to a natural toxin in drosophilids.G3 (Bethesda, Md.) · 2026Article
- Convergent Evolution and the Epigenome.Epigenomes · 2025Review
- Article
- Beneficial reversal of dominance maintains a large-effect resistance polymorphism under fluctuating insecticide selection.Nature ecology & evolution · 2025Article
- Epistasis among clustered lineage-specific adaptive amino acid substitutions in the Drosophila Trio protein.bioRxiv : the preprint server for biology · 2025Article
- Toxicity of novel neurotoxic insecticides on Tetranychus urticae and various phytophagous and predatory mite species.Experimental & applied acarology · 2025Article
- The shape of discovery: a journey through genetics, coevolution, and a scientific life.Genetics · 2025Article
- Mutations of the complex I PSST target gene confers acaricide resistance and a fitness cost in Panonychus citri.BMC biology · 2025Article
- Alternative Splicing in TRPA1 Drives Sensory Adaptation to Electrophiles in Drosophilids.bioRxiv : the preprint server for biology · 2025Article
- The modern pattern of insect herbivory predates the advent of angiosperms by 60 My.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Volatiles of the PredatorInsects · 2024Article
- Rapid predator-prey balance shift follows critical-population-density transmission between cod (Gadus morhua) and capelin (Mallotus villosus).Communications biology · 2024Article
- Contributions of γ-Aminobutyric Acid (GABA) Receptors for the Activities ofPlants (Basel, Switzerland) · 2024Article
- Effects of RDL GABA Receptor Point Mutants on Susceptibility to Meta-Diamide and Isoxazoline Insecticides inInsects · 2024Article
- Host genetics and larval host plant modulate microbiome structure and evolution underlying the intimate insect-microbe-plant interactions inEcology and evolution · 2024Article
- Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 3 countries.
Funding
Abstract
The molecular mechanisms of coevolution between plants and insects remain elusive. GABA receptors are targets of many neurotoxic terpenoids, which represent the most diverse array of natural products known. Over deep evolutionary time, as plant terpene synthases diversified in plants, so did plant terpenoid defence repertoires. Here we show that herbivorous insects and their predators evolved convergent amino acid changing substitutions in duplicated copies of the Resistance to dieldrin (Rdl) gene that encodes the GABA receptor, and that the evolution of duplicated Rdl and terpenoid-resistant GABA receptors is associated with the diversification of moths and butterflies. These same substitutions also evolved in pests exposed to synthetic insecticides that target the GABA receptor. We used in vivo genome editing in Drosophila melanogaster to evaluate the fitness effects of each putative resistance mutation and found that pleiotropy both facilitates and constrains the evolution of GABA receptor resistance. The same genetic changes that confer resistance to terpenoids across 300 Myr of insect evolution have re-evolved in response to synthetic analogues over one human lifespan.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.